Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody

Internal Medicine
Tatsuya KusumotoTomoko Betsuyaku

Abstract

A 72-year-old man was admitted due to dyspnea on exertion with interstitial shadows and elevated serum creatinine kinase (CK). Despite a close examination, which included magnetic resonance imaging (MRI), we could not diagnose myopathy. Prednisolone was administered and gradually tapered. One year later, anti-signal recognition particle (SRP) antibody was confirmed and he was re-admitted for hypoxemia with elevated CK. MRI revealed muscle edema and a histopathological examination of a muscle biopsy specimen showed necrotizing myopathy. Prednisolone, cyclosporine, and intravenous immunoglobulin were administered. Physicians should carefully monitor muscle symptoms and serum CK levels in cases of interstitial lung disease with anti-SRP antibodies.

References

Feb 13, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Sep 1, 1990·Arthritis and Rheumatism·I N TargoffF W Miller
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W H ReevesG Blobel
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P Walter, G Blobel
Sep 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·T MillerA Pestronk
May 9, 2006·Annals of the Rheumatic Diseases·G J D HengstmanB G M van Engelen
Jan 16, 2007·American Journal of Respiratory and Critical Care Medicine·Joo Hun ParkThomas V Colby
Jul 30, 2009·Rheumatology International·Felix WantkeSabine Schmaldienst
May 13, 2015·Orphanet Journal of Rare Diseases·Shigeaki SuzukiIchizo Nishino
Oct 2, 2015·Clinical Reviews in Allergy & Immunology·Minoru SatohEdward K L Chan
Feb 26, 2016·BMJ : British Medical Journal·Stephen C Mathai, Sonye K Danoff
Dec 4, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Ryuichi TogawaMitsuru Munakata

❮ Previous
Next ❯

Citations

Apr 10, 2020·International Journal of Molecular Sciences·Andrey L KaramyshevZemfira N Karamysheva
Oct 13, 2020·Journal of Clinical Biochemistry and Nutrition·Hiroko MoritaKazuhiro Kurasawa
Oct 24, 2020·Nature Reviews. Rheumatology·Yves AllenbachOlivier Boyer
Mar 23, 2021·Respiratory Medicine Case Reports·Samantha BaahDaniel Lachant
Jan 15, 2019·Autoimmunity Reviews·Céline AnquetilYves Allenbach
Aug 3, 2021·Frontiers in Immunology·Andrea FariniYvan Torrente

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assays
ELISA
immunoprecipitation assay
biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.