Development of neuropathic pain is affected by bedding texture in two models of peripheral nerve injury in rats

Neuroscience Letters
Ian RobinsonTheo F Meert

Abstract

It has long been known that there are numerous genetic and environmental factors that affect the in vivo research of neuropathic pain. In this letter, we describe the impact that bedding material can have on the development of neuropathic pain behaviors in rodents. In two models of neuropathic pain, the Chronic Constriction Injury (CCI) and the partial axotomy, we demonstrated that features of the sawdust on which the animals are housed during experimentation have a clear effect on the development of mechanical hyperalgesia and chemical hypersensitivity. Rats housed on coarse sawdust presented with a much-reduced response to a pinprick and acetone test compared to counterparts housed on fine sawdust. It is therefore concluded that the development of specific stimulus modalities of neuropathic pain behavior following peripheral nerve injury can be influenced in part by environmental factors, in this case bedding texture.

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Citations

Mar 5, 2009·Nature Reviews. Neuroscience·Jeffrey S Mogil
Oct 13, 2015·The Journal of Pain : Official Journal of the American Pain Society·Francie MoehringCheryl L Stucky
Feb 18, 2014·British Journal of Pharmacology·N Percie du Sert, A S C Rice
Mar 10, 2015·Behavioural Brain Research·Guy A HigginsSandy Thevarkunnel
Mar 28, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Paul GrayTess Cramond
Jul 15, 2020·PLoS Biology·Nathalie Percie du SertHanno Würbel
May 3, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Atsushi Sasaki, Yasushi Kuraishi
Oct 24, 2020·ILAR Journal·Vanessa K LeeMichael J Huerkamp

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