Development of nitrosyl ruthenium complex-loaded lipid carriers for topical administration: improvement in skin stability and in nitric oxide release by visible light irradiation

Journal of Pharmaceutical and Biomedical Analysis
Franciane Marquele-OliveiraRenata Fonseca Vianna Lopez

Abstract

The prominent nitric oxide (NO) donor [Ru(terpy)(bdqi)NO](PF(6))(3) has been synthesized and evaluated with respect to noteworthy biological effects due to its NO photorelease, including vascular relaxation and melanoma cell culture toxicity. The potential for delivering NO in therapeutic quantities is tenable since the nitrosyl ruthenium complex (NRC) must first reach the "target tissue" and then release the NO upon stimulus. In this context, NRC-loaded lipid carriers were developed and characterized to further explore its topical administration for applications such as skin cancer treatment. NRC-loaded solid lipid nanoparticles (SLN) and nanostructured lipid carriers were prepared via the microemulsification method, with average diameters of 275+/-15 nm and 211+/-31 nm and zeta potentials of -40.7+/-10.4 mV and -50.0+/-7.5 mV, respectively. In vitro kinetic studies of NRC release from nanoparticles showed sustained release of NRC from the lipid carriers and illustrated the influence of the release medium and the lyophilization process. Stability studies showed that NO is released from NRC as a function of temperature and time and due to skin contact. The encapsulation of NRC in SLN followed by its lyophilization, significantl...Continue Reading

References

Aug 13, 1994·BMJ : British Medical Journal·P Vallance, J Collier
Apr 11, 2002·Chemical Reviews·Anthony R Butler, Ian L Megson
Dec 3, 2003·Journal of the American Chemical Society·Marilia G SauaiaRoberto S da Silva
May 12, 2004·Nitric Oxide : Biology and Chemistry·Daniella BonaventuraLusiane M Bendhack
Mar 23, 2005·Dalton Transactions : an International Journal of Inorganic Chemistry·Konstantina KaridiJan Reedijk
Aug 17, 2005·Current Topics in Medicinal Chemistry·Gregory R J Thatcher
Sep 10, 2005·Photodermatology, Photoimmunology & Photomedicine·Michael Weichenthal, Thomas Schwarz
Oct 20, 2006·Journal of Nanoscience and Nanotechnology·A S PattaniVandana B Patravale
Oct 20, 2006·Journal of Nanoscience and Nanotechnology·K RuckmaniP A Ganeshkumar
Mar 10, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Veerawat TeeranachaideekulRainer H Müller
Jul 24, 2007·International Journal of Pharmaceutics·Kumar A ShahVandana B Patravale
Jul 27, 2007·International Journal of Pharmaceutics·Medha Joshi, Vandana Patravale
Apr 29, 2008·Free Radical Biology & Medicine·Douglas D ThomasDavid A Wink
Dec 3, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Stephânia F TaveiraRenata F V Lopez
Apr 14, 2009·Nitric Oxide : Biology and Chemistry·Anderson Rodrigo Moraes de OliveiraPierina Sueli Bonato
Oct 1, 2008·Coordination Chemistry Reviews·Michael J Rose, Pradip K Mascharak

❮ Previous
Next ❯

Citations

May 16, 2013·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Oscar Filevich, Roberto Etchenique
Jun 19, 2013·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Nichola A Smith, Peter J Sadler
Aug 27, 2011·Journal of Drug Delivery·Juliana SaraivaJuliana Maldonado Marchetti
May 31, 2013·World Journal of Surgical Oncology·Sheetal Korde ChoudhariVaishali Joshi
May 9, 2014·PLoS Neglected Tropical Diseases·Zumira A CarneiroVictor M Deflon
Aug 8, 2014·BioMed Research International·Chiara DianzaniGiuseppina Barrera
Aug 31, 2012·Journal of Drug Targeting·Md Asif IqbalJaved Ali
Dec 20, 2011·Nitric Oxide : Biology and Chemistry·Elia TfouniDouglas Wagner Franco
Feb 9, 2016·Future Science OA·Hongying LiangJoel M Friedman
May 13, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lígia Marquez AndradeStephânia Fleury Taveira
Mar 19, 2013·International Journal of Pharmaceutics·Valentina IannuccelliEliana Leo
Dec 3, 2014·Cancer Letters·M C F SimõesA A C C Pais
Dec 10, 2016·The Indian Journal of Medical Research·Sreemanti Das, Anisur Rahman Khuda-Bukhsh
Aug 11, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Pravin ShendeR S Gaud
May 3, 2013·Chemical Communications : Chem Comm·Nicolas P E Barry, Peter J Sadler
Nov 18, 2018·Current Medicinal Chemistry·Erzsébet CsányiSzilvia Berkó
Jan 25, 2012·Advanced Functional Materials·Michele C JenGuillermo A Ameer
Oct 31, 2020·Chemical Reviews·Roy WeinstainPetr Klán

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis