PMID: 6978754Apr 1, 1982Paper

Development of nodal and paranodal membrane specializations in amphibian peripheral nerves

Brain Research
J H Tao-Cheng, Jack Rosenbluth

Abstract

Peripheral nerves from the hind legs of frog tadpoles were examined in order to ascertain the pattern of development of nodal and paranodal specializations in myelinated fibers. In thin sections the earliest detectable node-related specializations resemble "intermediate" junctions between axons and Schwann cell processes. These occur in individually ensheathed axons near the edges of the sheath segments and could represent early nodal or paranodal components or transient structures. The characteristic nodal "undercoating" is indistinct and highly variable in thickness in immature fibers and its density is lower in developing nodes than in adult nodes. Corresponding freeze-fracture replicas of developing axons demonstrate aggregates of nodal E face particles whose concentration is lower than that in the adult. Such aggregates usually occur immediately adjacent to Schwann cell indentations, even though early in development the latter may not exhibit the paracrystalline pattern seen in the adult paranodal axolemma. On rare occasions, node-like particle aggregates and presumptive nodal undercoatings have been observed without recognizable paranodal junctions or indentations nearby. However, neither specialization has been found in ...Continue Reading

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Citations

Feb 1, 1985·Journal of Neurocytology·J A BlackS A Gilmore
Mar 1, 1991·Journal of Neurocytology·W L MaxwellM Sturatis
Jul 1, 1991·Journal of Neurocytology·N Shirasaki, J Rosenbluth
Aug 1, 1987·Journal of Neurocytology·J Rosenbluth
Sep 1, 1983·Brain Research·J H Tao-Cheng, J Rosenbluth
Jan 1, 1989·Progress in Neurobiology·R D FieldsM H Ellisman
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J Rosenbluth
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·C V Melendez-VasquezJ L Salzer
Jan 1, 1990·Annals of the New York Academy of Sciences·J Rosenbluth
Dec 5, 2013·Human Molecular Genetics·Gillian HunterThomas H Gillingwater
Feb 19, 2009·Journal of Neuroscience Research·Jack Rosenbluth
Jan 27, 2009·Journal of Neuroscience Research·Liliana PedrazaDavid Colman
Oct 15, 2003·Neuron·James L Salzer
Aug 1, 1996·Microscopy Research and Technique·J M Schröder
Oct 20, 1998·Journal of Neurobiology·I Vabnick, P Shrager
Jun 28, 1985·Science·S G Waxman, J M Ritchie

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