Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP and IGF-I in the rat retina

Experimental Eye Research
W CaoM M LaVail

Abstract

Focal mechanical injury to the retina substantially increases basic fibroblast growth factor (bFGF) and ciliary neurotrophic factor (CNTF) mRNA expression, accompanied by a transient increase in FGFR-1 mRNA, and this response is thought to protect photoreceptors near the injury site from inherited and light-induced retinal degenerations. We have now examined retinal gene expression of the principal survival factors involved in the response to injury in normal rats as a function of postnatal age both in normal and injured retinas. Sprague-Dawley rats were injured in one eye by needle incision through the retina at postnatal day (P) 10, 22, 35, 60, 90, 120 and 180. The other eye was uninjured and served as the control. Retinas were taken 1 day post-injury. Northern blot analysis was performed to determine the mRNA expression of the following factors and receptors: bFGF and acidic fibroblast growth factors (aFGF) and FGF receptor-1 (FGFR-1); CNTF and CNTF receptor alpha (CNTFR-alpha); brain-derived neurotrophic factor (BDNF) and its receptor trk B; and insulin-like growth factor-I (IGF-I) and IGF-I receptor (IGF-IR); glial fibrillary acidic protein (GFAP) and opsin. In the uninjured control eyes, mRNA expression of most of the fac...Continue Reading

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Citations

Apr 30, 2010·In Vitro Cellular & Developmental Biology. Animal·Kamla DuttIfeoma Ezeonu
Sep 16, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hua XuYa-Dong Huang
Aug 21, 2003·The British Journal of Ophthalmology·K H C WuP L Penfold
Mar 29, 2007·Investigative Ophthalmology & Visual Science·Kenneth P GreenbergJohn G Flannery
May 26, 2007·Investigative Ophthalmology & Visual Science·R Brooks WilsonBärbel Rohrer
Jul 27, 2007·Investigative Ophthalmology & Visual Science·Bruce A BerkowitzAlgis J Vingrys
May 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tonia VincentJeremy Saklatvala
Feb 13, 2013·Experimental Eye Research·Fatemeh ValamaneshClaudine Versaux-Botteri
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