Development of novel animal infection models for the study of acute and chronic Burkholderia pseudomallei pulmonary infections

Microbes and Infection
Erin J van SchaikDonald E Woods

Abstract

Burkholderia pseudomallei causes the disease melioidosis. The most common clinical presentation of melioidosis is pneumonia which can occur in acute and chronic forms. The tsunami of 2004 demonstrated a new risk factor for the acquisition of melioidosis and resulted in the proposal that direct delivery of B. pseudomallei into the lungs may result in the enhanced ability of this pathogen to cause disease. In the present studies, we present the development and characterization of rat models of acute and chronic pulmonary melioidosis, and we have utilized these models to demonstrate that direct delivery of B. pseudomallei into the lungs does indeed result in the enhanced ability of this pathogen to cause disease. Importantly, the rat lung infection models for melioidosis can quantify differences in virulence between individual B. pseudomallei wild type strains during both acute and chronic infections. Further, the histopathology associated with pulmonary melioidosis in the rat resembles that seen in tuberculosis. B. pseudomallei microarrays were used to characterize gene expression patterns during chronic pulmonary infections. Transcriptional profiling at several time points during chronic infection revealed that a wide range of g...Continue Reading

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Citations

Aug 5, 2009·PLoS Neglected Tropical Diseases·Vanaporn WuthiekanunSharon J Peacock
Feb 7, 2014·The American Journal of Tropical Medicine and Hygiene·Blandine RammaertArnaud Tarantola
Mar 3, 2010·Expert Review of Anti-infective Therapy·D Mark EstesAlfredo G Torres
Jun 28, 2011·The American Journal of Pathology·Laura ConejeroGregory J Bancroft
Apr 26, 2015·Applied and Environmental Microbiology·Noppadol PrasertsincharoenJennifer Elliman

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