Development of Novel Microparticles for Effective Delivery of Thymol and Lauric Acid to Pig Intestinal Tract

Journal of Agricultural and Food Chemistry
Faith A OmonijoChengbo Yang

Abstract

Antibiotics have been widely supplemented in feeds at subtherapeutic concentrations to prevent postweaning diarrhea and increase the overall productivity of pigs. However, the emergence of antimicrobial-resistant bacteria worldwide has made it urgent to minimize the use of in-feed antibiotics. The development of promising alternatives to in-feed antibiotics is crucial for maintaining the sustainability of swine production. Both medium-chain fatty acids (MCFA) and essential oils exhibit great potential to postweaning diarrhea; however, their direct inclusion has compromised efficacy because of several factors including low stability, poor palatability, and low availability in the lower gut. Therefore, the objective of this study was to develop a formulation of microparticles to deliver a model of essential oil (thymol) and MCFA (lauric acid). The composite microparticles were produced by the incorporation of starch and alginate through a melt-granulation process. The release of thymol and lauric acid from the microparticles was in vitro determined using simulated salivary fluid (SSF), simulated gastric fluid (SGF), and simulated intestinal fluid (SIF), consecutively. The microparticles prepared with 2% alginate solution displaye...Continue Reading

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Citations

Feb 23, 2019·Materials·Alexandra Muñoz-BonillaMarta Fernández-García
Jul 27, 2020·Translational Animal Science·Janghan ChoiChengbo Yang
Dec 18, 2020·Animals : an Open Access Journal From MDPI·Janghan Choi, Woo Kyun Kim
Aug 10, 2021·Frontiers in Bioengineering and Biotechnology·Gloria María Pontes-QueroBlanca Vázquez-Lasa
Mar 24, 2020·ACS Omega·Noémie Van NotenJoris Michiels

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