Development of novel predictive miRNA/target gene pathways for colorectal cancer distance metastasis to the liver using a bioinformatic approach.

PloS One
Precious Takondwa MakondiYu-Jia Chang

Abstract

Liver metastases are the major cause of colorectal cancer (CRC)-related deaths. However, there is no reliable clinical predictor for CRC progression to liver metastasis. In this study, we investigated possible predictors (miRNAs and biomarkers) for clinical application. The Gene Expression Omnibus (GEO) datasets GSE49355, GSE41258 and GSE81558 for genes and GSE54088 and GSE56350 for miRNAs were used to identify common differentially expressed genes (DEGs) and miRNAs between primary CRC tissues and liver metastases. The identified miRNAs and their targets from the DEGs were verified in datasets comprising gene, miRNA and miRNA exosome profiles of CRC patients with no distant metastases (M0) and distant metastases (M1); the interaction networks and pathways were also mapped. There were 49 upregulated and 13 downregulated DEGs and 16 downregulated and 14 upregulated miRNAs; between the DEGs and miRNA targets, there were five upregulated and four downregulated genes. MiR-20a was strongly correlated with the status of liver metastasis. MiR-20a, miR499a, and miR-576-5p were highly correlated with the metastatic outcomes. MiR-20a was significantly highly expressed in the M1 group. In an analysis of the miRNA target genes, we found tha...Continue Reading

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Citations

Aug 23, 2019·International Journal of Molecular Sciences·Andrea AngiusMaria Rosaria De Miglio
Dec 19, 2020·Molecular Therapy. Nucleic Acids·Liaoran NiuDaiming Fan
Feb 11, 2021·International Journal of Molecular Sciences·Andrea AngiusMaria Rosaria De Miglio
May 15, 2021·OncoTargets and Therapy·Wubin ZhengWeiwei Tang

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Datasets Mentioned

BETA
GSE29623
GSE39582
GSE39833
GSE54088
and
GSE56350
GSE49355
GSE41258
GSE81558

Methods Mentioned

BETA
chip

Software Mentioned

miRanda
Venny
GEO2R
Reactome FI
mirDIP
Cytoscape
Ensembl
GeneMANIA
DIANA
reactome Cytoscape

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