Development of novel surface coating composed of MDPB and MPC with dual functionality of antibacterial activity and protein repellency.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Pasiree ThongthaiSatoshi Imazato

Abstract

Resin-based reconstructive/restorative materials with antibacterial effects are potentially useful for preventing dental and oral diseases. To this end, the immobilization of an antibacterial component on the surface of a resin by incorporating polymerizable bactericide such as a quaternary ammonium compound-monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) is an effective technique. However, the effectiveness of immobilized bactericide is reduced by salivary protein coverage. We address this issue by utilizing 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, which exhibits protein repellency, with MDPB to fabricate a novel copolymer, which served as a surface coating on a methacrylate-based resin. This coating provided a more hydrophilic surface than that provided by MDPB coating and reduced the adsorption of bovine serum albumin and salivary protein. To evaluate bacterial growth on the contact surface, Streptococcus mutans suspension was placed on the coated specimen. After 24-h incubation, MDPB/MPC copolymer exhibited killing effects against S. mutans. Moreover, confocal laser scanning microscopy and scanning electron microscopy were used to evaluate biofilm formation after 48-h incubation in S. mutans suspen...Continue Reading

References

Jan 1, 1991·Journal of Biomaterials Science. Polymer Edition·T UedaN Nakabayashi
Jun 1, 1995·Journal of Dentistry·S ImazatoJ F McCabe
Aug 1, 1994·Journal of Dental Research·S ImazatoR R Russell
Feb 11, 1998·Journal of Biomedical Materials Research·K IshiharaN Nakabayashi
Sep 25, 2001·Dental Materials : Official Publication of the Academy of Dental Materials·N EbiS Ebisu
Feb 15, 2002·Advances in Dental Research·U LendenmannF G Oppenheim
Apr 11, 2003·Dental Materials : Official Publication of the Academy of Dental Materials·Satoshi ImazatoFranklin R Tay
Jun 18, 2003·Biomaterials·Satoshi ImazatoRoy R B Russell
Feb 8, 2005·European Journal of Oral Sciences·Christian HannigThomas Attin
Aug 19, 2008·European Journal of Oral Sciences·Thaís Cachuté ParadellaAntonio Olavo Cardoso Jorge
Mar 31, 2011·Journal of Dental Research·K HirotaY Miyake
Jul 23, 2011·Virulence·Ruijie HuangRichard L Gregory
Aug 1, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Satoshi ImazatoHockin H K Xu
Oct 18, 2012·Science and Technology of Advanced Materials·Yasuhiko Iwasaki, Kazuhiko Ishihara
Jan 15, 2020·Dental Materials Journal·Satoshi ImazatoHaruaki Kitagawa

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Citations

Oct 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing XueMing Wang
Jun 10, 2021·Science and Technology of Advanced Materials·Suphatra Hiranphinyophat, Yasuhiko Iwasaki
Jun 9, 2021·Colloids and Surfaces. B, Biointerfaces·Hiroki NakanoYasuhiko Iwasaki
Jul 25, 2021·Journal of Dental Research·P ThongthaiS Imazato

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