PMID: 8589737Jan 1, 1996Paper

Development of obesity following inactivation of a growth hormone transgene in mice

Transgenic Research
D PompJ D Murray

Abstract

Mice with a temporally regulatable ovine metallothionein 1a--ovine growth hormone transgene (oMT1a-oGH) were utilized to study the effects of withdrawal of elevated circulating levels of growth hormone (GH) on growth and body composition. The transgene was activated from 21-42 days of age by provision of zinc sulfate in the drinking water. At 42 days, mice were allocated to either activated transgenic (remain on zinc sulfate) or inactivated transgenic (removal of zinc sulfate) groups, and to receive either ad libitum or restricted (80-90% of ad libitum) access to feed. Non-transgenic control mice were treated similarly. Body weights and intakes were recorded weekly. Mice were killed at 70 d and epididymal and subcutaneous fat pads, trimmed hind carcass and various organs were weighed. The main findings of this study are: (1) food-restricted mice possessing an activated oMT1a-oGH transgene fail to demonstrate increased growth, but exhibit significantly reduced levels of fat (P < 0.05) relative to all other genotype x feed level combinations; and (2) inactivation of the oMT1a-oGH transgene, following a period of elevated GH levels, leads to development of obesity as evidenced by two to three fold increases in epididymal and subcu...Continue Reading

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Citations

Oct 6, 2005·Transgenic Research·A D ThomasA M Oberbauer
Oct 24, 2007·Biological Trace Element Research·Satish Kumar Taneja, Reshu Mandal
Oct 25, 2008·Endocrinology·Amanda J PalmerDarlene E Berryman
May 15, 2001·Biochemical and Biophysical Research Communications·X L ChenC A Baile
Mar 5, 2013·Endocrinology·Sarah K McMenaminDavid M Parichy
Jan 1, 2007·Obesity Research & Clinical Practice·Susan M SennJohn D Wark
Jul 3, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Darlene E BerrymanJohn J Kopchick
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Apr 8, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Darlene E BerrymanJohn J Kopchick
Sep 17, 2013·Molecular and Cellular Endocrinology·John J KopchickDarlene E Berryman
Mar 25, 2006·Endocrinology·Darlene E BerrymanJohn J Kopchick
Apr 23, 2008·Current Protocols in Neuroscience·Matthias Tschöp, Mark L Heiman
Nov 10, 2001·American Journal of Physiology. Endocrinology and Metabolism·F FrickJ Oscarsson
May 9, 2003·American Journal of Physiology. Endocrinology and Metabolism·Bob OlssonJan Törnell

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