Development of oncolytic virotherapy: from genetic modification to combination therapy

Frontiers of Medicine
Qiaoshuai LanLu Lu

Abstract

Oncolytic virotherapy (OVT) is a novel form of immunotherapy using natural or genetically modified viruses to selectively replicate in and kill malignant cells. Many genetically modified oncolytic viruses (OVs) with enhanced tumor targeting, antitumor efficacy, and safety have been generated, and some of which have been assessed in clinical trials. Combining OVT with other immunotherapies can remarkably enhance the antitumor efficacy. In this work, we review the use of wild-type viruses in OVT and the strategies for OV genetic modification. We also review and discuss the combinations of OVT with other immunotherapies.

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Sep 13, 2020·Cells·Simone HagerMatthias Bros
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Apr 28, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Noraini Abd-Aziz, Chit Laa Poh

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