Development of oral cancer tissue-mimicking phantom based on polyvinyl chloride plastisol and graphite for terahertz frequencies.

Journal of Biomedical Optics
Tianmiao ZhangMikhail K Khodzitskiy

Abstract

A new concept of a biotissue phantom for terahertz (THz) biomedical applications is needed for reliable and long-term usage. We aimed to develop a new type of biotissue phantom without water content and with controllable THz optical properties by applying graphite powders into a polyvinyl chloride plastisol (PVCP) matrix and to give a numerical description to the THz optical properties of the phantoms using the Bruggeman model (BM) of the effective medium theory (EMT). The THz optical properties of graphite and the PVCP matrix were measured using THz time-domain spectroscopy, which works in the frequency range from 0.1 to 1 THz. Two phantoms with 10% and 12.5% graphite were fabricated to evaluate the feasibility of describing phantoms using the EMT. The EMT then was used to determine the concentration of graphite required to mimic the THz optical properties of human cancerous and healthy oral tissue. The phantom with 16.7% of graphite has the similar THz optical properties as human cancerous oral tissue in the frequency range of 0.2 to 0.7 THz. The THz optical properties of the phantom with 21.9% of graphite are close to those of human healthy oral tissue in the bandwidth from 0.6 to 0.8 THz. Both the refractive index and absor...Continue Reading

References

Dec 9, 2004·Physics in Medicine and Biology·Gillian C WalkerDavid S Brettle
Feb 23, 2012·Journal of Biomedical Optics·Anthony J FitzgeraldVincent P Wallace
Dec 21, 2012·Quantitative Imaging in Medicine and Surgery·Calvin YuEmma Pickwell-Macpherson
Jul 24, 2014·IEEE Journal of Biomedical and Health Informatics·Yookyeong Carolyn SimJoo-Hiuk Son
Jan 20, 2017·Biomedical Optics Express·Mariia BorovkovaMikhail Khodzitsky
Mar 16, 2018·Biomedical Optics Express·Bao C Q TruongVincent P Wallace
May 16, 2018·Biomedical Optics Express·Mariia BorovkovaIgor Meglinski

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