Abstract
To report a case of oral candidiasis that developed in a 70-year-old white female both upon initiation and rechallenge of extended-release bupropion therapy. A 70-year-old female with a past medical history of osteoarthritis, degenerative joint disease, and polycythemia vera developed oral candidiasis on 2 occasions following initiation of extended-release bupropion for the treatment of recurrent depression. During both instances, the reaction occurred with an increased dose of the medication, suggesting the adverse event may have been dose-related. The patient had no risk factors for oral candidiasis aside from dry mouth at baseline that reportedly worsened on bupropion. Though there are no other reports to our knowledge describing the development of oral candidiasis with bupropion, the likelihood of this having been an adverse reaction in this patient is probable as indicated by a calculated score of 8 from the Naranjo Algorithm. The adverse event appeared following bupropion administration and improved over time following its discontinuation. The adverse event reappeared following readministration of the agent, and no alternative causes were able to be identified. Additionally, the reaction occurred following an increase in ...Continue Reading
References
Feb 1, 1987·Journal of Dental Research·M M Schubert, K T Izutsu
Sep 1, 1984·Journal of Dental Research·H Ben-AryehD Gutman
Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Sep 1, 1995·Journal of Clinical Pharmacology·R A SweetC L DeVane
May 13, 1999·Clinical Therapeutics·E C SettleJ A Ascher
May 19, 2000·The Journal of Clinical Psychiatry·K L WeihsJ A Ascher
Sep 15, 2001·Obesity Research·K M GaddeK R Krishnan
Apr 3, 2002·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·J D VanderkooyR Michael Bagby
Jul 12, 2002·Drugs·Andrew J JohnstonBeth Bentley
Oct 24, 2002·Blood·Jerry L Spivak
Jan 31, 2003·The Journal of the American Dental Association·James Guggenheimer, Paul A Moore
Mar 12, 2004·Primary Care Companion to the Journal of Clinical Psychiatry·Molly R. FortnerP Murali Doraiswamy
Sep 14, 2004·Primary Care Companion to the Journal of Clinical Psychiatry·Stephen M. StahlSusan Learned-Coughlin
Jul 20, 2005·Primary Care Companion to the Journal of Clinical Psychiatry·Maurizio FavaJ Andrew Johnston
Sep 21, 2005·Archives of Dermatology·Richard E Kast, Eric L Altschuler
Jul 19, 2011·General Hospital Psychiatry·Chien-Kuan ChiangChih-Sung Liang
Nov 28, 2013·Postȩpy dermatologii i alergologii·Zuzanna SlebiodaAnna Kowalska
Nov 5, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Arun SinghAshutosh Agrawal