PMID: 11336843May 5, 2001Paper

Development of oral heparin therapy for prophylaxis and treatment of deep venous thrombosis

Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery
S R Money, J W York

Abstract

To review the current research and published literature regarding the development of oral heparin therapy for the prophylaxis and treatment of deep venous thrombosis. Currently, the accepted practice of prophylaxis and/or treatment of acute deep venous thrombosis (DVT) is intravenous or subcutaneous (SQ) heparin followed by oral warfarin or SC low molecular weight heparin (LMWH) therapy followed by warfarin. Both of which are less than ideal. More recently, advances have been made towards an effective oral heparin preparation that would resolve many of the drawbacks to the current therapies. A review of the current and relevant English literature identified via a search of the Medline database from January 1990 to present. Initial oral heparin therapy for DVT was unsuccessful due to presumed inadequate intestinal absorption as a result of heparin's molecular and structural characteristics. The development of oral heparin therapy, based on combining heparin with the carrier molecule Sodium N-(8[2-hydroxybenzoyl]amino) caprylate (SNAC) to enhance its intestinal absorption and bioavailability for the prophylaxis and treatment of DVT has been demonstrated to be effective in animal models. More recent efforts have been aimed at huma...Continue Reading

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Citations

Oct 22, 2008·Pharmaceutical Research·Bita Moazed, Linda M Hiebert
Jun 1, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sang Kyoon KimYoungro Byun
Jul 8, 2005·Thoracic Surgery Clinics·Mark H Meissner, Riyad Karmy-Jones
May 26, 2005·Thrombosis Research·Sang Kyoon KimYoungro Byun
Nov 7, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andreas Bernkop-SchnürchAlexander H Krauland
Aug 9, 2011·Annual Review of Pharmacology and Toxicology·Jawed FareedDebra Hoppensteadt
Mar 29, 2005·Journal of Pharmaceutical Sciences·Thierry SchmitzAndreas Bernkop-Schnürch
Feb 3, 2011·Medicinal Research Reviews·Rishi PaliwalSuresh P Vyas
Jul 24, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Linda M HiebertTilly Ping
Nov 22, 2005·Expert Opinion on Drug Delivery·Isabel Gomez-Orellana
Apr 14, 2012·Thrombosis Research·Eleonora Da PozzoRossella Di Stefano
Nov 26, 2009·Drug Development and Industrial Pharmacy·Julien Scala-BertolaPhilippe Maincent
Jul 18, 2002·Nature Reviews. Drug Discovery·Rebecca Lever, Clive P Page
Jun 21, 2019·Journal of Thrombosis and Haemostasis : JTH·Ingrid M BistervelsSaskia Middeldorp
Apr 17, 2007·The Journal of Pharmacology and Experimental Therapeutics·Bita Moazed, Linda M Hiebert
Sep 7, 2005·Journal of Pharmaceutical and Biomedical Analysis·Sang Kyoon KimYoungro Byun
Jan 19, 2007·Advances in Colloid and Interface Science·Aviram Spernath, Abraham Aserin

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