Abstract
Raising ostriches became an important economic activity after their products became commodities. The health of farm animals is of paramount importance, so assessing basic immunological responses is necessary to better understand health problems. We developed a method to obtain ostrich thrombocytes and macrophages. The thrombocytes died by apoptosis after 48 h in culture, and the macrophages expanded in size and increased the number of acidic compartments. Macrophages were activated by chicken interferon-γ, producing high levels of nitric oxide. Toxoplasma gondii was able to infect these macrophages, and activation controlled parasitic reproduction. T. gondii, however, persisted in these cells, and infection reduced the production of nitric oxide. These results are important for the future assessment of the basic cellular and immunobiology of ostriches and demonstrate T. gondii suppression of nitric oxide production.
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Mar 13, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Pollyana Maria de Oliveira PimentelFabiana Simão Machado
Mar 18, 2021·Memórias do Instituto Oswaldo Cruz·João Cláudio Damasceno-SáRenato Augusto DaMatta
Mar 9, 2018·Experimental Parasitology·Irene MalkwitzBerit Bangoura