Development of oxaliplatin encapsulated in magnetic nanocarriers of pectin as a potential targeted drug delivery for cancer therapy

Results in Pharma Sciences
Raj Kumar Dutta, Saurabh Sahu

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) and oxaliplatin (OHP) were in-situ encapsulated in pectin cross-linked with Ca(2+) forming 100-200 nm sized magnetically functionalized pectin nanocarriers, referred here as MP-OHP nanocarriers. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) studies revealed formation of spherical nanostructures. The magnetic measurements by vibration sample magnetometer (VSM) revealed high saturation magnetization (M s=45.65 emu/g). The superparamagnetic property of MP-OHP was confirmed from the blocking temperature (T B) determined from field cooled and zero field cooled magnetization, measured by superconducting quantum unit interference device (SQUID) magnetometry. The stability of the aqueous dispersion of MP-OHP nanocarriers was confirmed from its high zeta potential (-30.5 mV). The drug encapsulation efficiency (55.2±4.8% w/w) and the drug loading content (0.10±0.04 wt%) in MP-OHP nanocarriers were determined from corresponding platinum contents in OHP and MP-OHP batches measured by inductively coupled plasma mass spectrometry (ICPMS). These nanocarriers exhibited a sustained release of OHP in phosphate buffer solution maintained at pH 5.5 and 7.4, whe...Continue Reading

Citations

Jan 31, 2017·Environmental Science and Pollution Research International·Hala Y El-Kassas, Mary G Ghobrial
Sep 27, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Andrew B ServaisSteven J Mentzer
Sep 20, 2020·Advances in Colloid and Interface Science·Abdur RehmanSohail Khan
Jun 23, 2021·Pharmaceutical Development and Technology·Hakan Nazlı, Gülşah Gedik
Sep 2, 2015·Molecular Pharmaceutics·Imalka MunaweeraKenneth J Balkus

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