Development of papillary renal cell tumours is associated with loss of Y-chromosome-specific DNA sequences

The Journal of Pathology
G KovacsA Kovacs

Abstract

Twenty-two papillary renal cell tumours were analysed by Southern hybridization using eight DNA probes from homologous regions of the X and Y chromosomes and two Y-chromosome-specific DNA probes. Sixteen of the 19 papillary renal cell tumours of male patients showed the loss of Y-chromosome-specific sequences. No loss of heterozygosity was detected in three tumours that developed in females. The frequency of loss of the Y chromosome was established in 50 non-papillary renal cell carcinomas as well. Only seven of the 31 non-papillary renal cell carcinomas obtained from male patients had lost the Y-chromosome-specific sequences, whereas no allelic loss was found in 19 non-papillary tumours obtained from female patients. Papillary renal cell tumours show a strong male preponderance (6:1) and loss of Y chromosome in 84 per cent of the cases, whereas non-papillary renal cell carcinomas show only a slight male preponderance (1.5:1) and the Y chromosome is lost in only 22 per cent of the cases. These data suggest that a tumour suppressor gene is localized at one of the homologous regions of the X and Y chromosomes, the homozygous inactivation of which is associated with the development of papillary renal cell tumours.

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Sep 27, 1996·International Journal of Cancer. Journal International Du Cancer·T DijkhuizenW Henn
Sep 1, 1995·Genes, Chromosomes & Cancer·T DijkhuizenB de Jong
Nov 19, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Manuel Valladares AyerbesLuis Miguel Antón Aparicio
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May 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marija VelickovicStefan K G Grebe

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