Development of partial life-cycle experiments to assess the effects of endocrine disruptors on the freshwater gastropod Lymnaea stagnalis: a case-study with vinclozolin.

Ecotoxicology
Virginie DucrotLaurent Lagadic

Abstract

Long-term effects of endocrine disruptors (EDs) on aquatic invertebrates remain difficult to assess, mainly due to the lack of appropriate sensitive toxicity test methods and relevant data analysis procedures. This study aimed at identifying windows of sensitivity to EDs along the life-cycle of the freshwater snail Lymnaea stagnalis, a candidate species for the development of forthcoming test guidelines. Juveniles, sub-adults, young adults and adults were exposed for 21 days to the fungicide vinclozolin (VZ). Survival, growth, onset of reproduction, fertility and fecundity were monitored weekly. Data were analyzed using standard statistical analysis procedures and mixed-effect models. No deleterious effect on survival and growth occurred in snails exposed to VZ at environmentally relevant concentrations. A significant impairment of the male function occurred in young adults, leading to infertility at concentrations exceeding 0.025 μg/L. Furthermore, fecundity was impaired in adults exposed to concentrations exceeding 25 μg/L. Biological responses depended on VZ concentration, exposure duration and on their interaction, leading to complex response patterns. The use of a standard statistical approach to analyze those data led to ...Continue Reading

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Citations

Jul 31, 2012·Ecotoxicology·Elke I ZimmerS A L M Kooijman
Jun 4, 2014·Environmental Science & Technology·Marie Laure Delignette-MullerSandrine Charles
Mar 12, 2016·Aquatic Toxicology·Mónica AquilinoJosé-Luis Martínez-Guitarte
Apr 9, 2013·Integrated Environmental Assessment and Management·Roman Ashauer, Colin D Brown
Sep 22, 2011·Environmental Toxicology and Chemistry·Stephanie C Plautz, Christopher J Salice
Sep 16, 2014·Regulatory Toxicology and Pharmacology : RTP·Virginie DucrotLaurent Lagadic
Jun 21, 2014·The Science of the Total Environment·Arnaud GiustiVirginie Ducrot
Jul 16, 2016·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Burkard T WatermannLeah Wollenberger
Dec 22, 2017·Environmental Toxicology and Chemistry·Bridgette N FidderChristopher J Salice
Feb 7, 2013·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Claudia SchmittEric de Deckere
Dec 24, 2018·Ecotoxicology and Environmental Safety·Mónica AquilinoJosé-Luis Martínez-Guitarte

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