Development of partial-thickness articular cartilage injury in a rabbit model

Clinical Orthopaedics and Related Research
E J P JansenR Kuijer

Abstract

In humans, partial-thickness cartilage lesions frequently result in premature osteoarthritis. While rabbits often are used as a model for partial-thickness cartilage lesions, the natural course of cartilage surrounding such a lesion is largely unknown. We developed a rabbit model of a chronic partial-thickness cartilage defect and asked whether these defects led to (1) deterioration of surrounding cartilage macroscopically and microscopically (increased Mankin score) and (2) disturbances in proteoglycan metabolism. In 55 rabbits, we created a 4-mm-diameter partial-thickness cartilage defect on one medial femoral condyle. The surrounding cartilage was characterized during the course of 26 weeks. Contralateral knees were sham-operated. In experimental knees, we found cartilage softening and fibrillation at 13 and 26 weeks. High Mankin scores observed at 1 week were partially restored at 13 weeks but worsened later and were most pronounced at 26 weeks. Mankin scores in the experimental groups were worse at 1 and 26 weeks when compared with the sham groups. Mankin scores at 26 weeks improved compared with 1 week in the sham groups. Disturbances in proteoglycan metabolism were less evident. In this rabbit model, a partial-thickness ...Continue Reading

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Citations

Aug 8, 2012·Stem Cell Reviews and Reports·Andrea PreitschopfMario Mikula
Oct 19, 2011·Cell and Tissue Research·Hiroaki TsuruokaKazuhisa Takahashi
Mar 23, 2012·Journal of Tissue Engineering and Regenerative Medicine·P J EmansR Kuijer
Feb 21, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kyla D HuebnerCyril B Frank
Nov 20, 2014·Cell and Tissue Research·Shunsuke MukoyamaKazuhisa Takahashi
Nov 2, 2020·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Tamás OláhHenning Madry

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