Development of pH-responsive biopolymer-silica composites loaded with Larrea divaricata Cav. extract with antioxidant activity

Colloids and Surfaces. B, Biointerfaces
María Inés Alvarez EchazúMartin Federico Desimone

Abstract

A detailed study of biomaterials is mandatory to comprehend their feasible biomedical applications in terms of drug delivery and tissue regeneration. Particularly, mucoadhesive biopolymers such as chitosan (chi) and carboxymethylcellulose (CMC) have become interesting biomaterials regards to their biocompatibility and non-toxicity for oral mucosal drug delivery. In this work, pH-responsive biopolymer-silica composites (Chi-SiO2, Chi-CMC-SiO2) were developed. These two types of composites presented a different swelling behavior due to the environmental pH. Moreover, the nanocomposites were loaded with aqueous Larrea divaricata Cav. extract (Ld), a South American plant which presents antioxidant properties suitable for the treatment of gingivoperiodontal diseases. Chi-CMC-SiO2 composites showed the highest incorporation and reached the 100% of extract release in almost 4 days while they preserved their antioxidant properties. In this study, thermal and swelling behavior were pointed out to show the distinct water-composite interaction and therefore to evaluate their mucoadhesivity. Furthermore, a cytotoxicity test with 3T3 fibroblasts was assessed, showing that in both composites the addition of Larrea divaricata Cav. extract inc...Continue Reading

Citations

Jul 8, 2020·International Journal of Molecular Sciences·Sofia MunicoyMartin F Desimone
Oct 8, 2019·Current Pharmaceutical Design·Juan M GaldopórporaMartin F Desimone
Dec 18, 2020·Frontiers in Chemistry·Lihua SuiKelong Ai
Aug 29, 2021·Pharmaceuticals·Gustavo MoraesWalter L Siqueira

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