PMID: 9184994Jun 16, 1997Paper

Development of phrenic motoneuron morphology in the fetal rat

The Journal of Comparative Neurology
D W Allan, John J Greer

Abstract

This study examined the morphological changes that a homogeneous mammalian spinal motoneuron population undergoes during foetal development. Retrograde labelling of the phrenic nerve with the carbocyanine dye, DiI, was used to visualise developmental changes in phrenic motoneuron morphology within the cervical spinal cord of perinatal rats from embryonic day (E) 13.5 to birth (ca. E21). Groups of intimately associated phrenic somata had migrated into the ventromedial region of cervical segments C3-C6 by E14. This migration was followed by their progressive compaction into a tightly aligned column by E18. During this period, close contact was maintained between phrenic somata throughout the motor pool, suggestive of the presence of gap junctions. From E15 to E18, extensive dendritic arborisations fanned out dorsolaterally and ventromedially into the white matter and the floor plate. By E19, however, dendritic fasciculation and retraction and the extension of newly formed rostrocaudally projecting dendrites had resulted in the approximation of the dendritic morphology observed at birth. These data demonstrate that morphological maturation of phrenic motoneurons occurs subsequently to the onset of functional recruitment and the ar...Continue Reading

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Jun 16, 1997·The Journal of Comparative Neurology·D W Allan, J J Greer

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Citations

Jul 1, 2005·Molecular and Cellular Biology·Frédérique VaroqueauxNils Brose
Apr 12, 2008·Journal of Applied Physiology·Carlos B Mantilla, Gary C Sieck
Oct 30, 2012·Nature Neuroscience·Polyxeni PhilippidouJeremy S Dasen
May 7, 2009·Experimental Neurology·Yonglu Huang, Harry G Goshgarian
Nov 23, 2005·Respiratory Physiology & Neurobiology·James Duffin, Yan Mei Li
Jun 14, 2005·Respiratory Physiology & Neurobiology·John J Greer, Gregory D Funk
Jun 10, 2015·Experimental Neurology·Michael George Zaki Ghali, Vitaliy Marchenko
Dec 10, 2009·Neuropharmacology·Xianglian Ni, Miguel Martin-Caraballo
Nov 15, 2005·The Journal of Physiology·John J GreerKlaus Ballanyi
May 2, 2002·The Journal of Comparative Neurology·Rebecca L AndersonIan L Gibbins
May 1, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Niels BeurskensDick Tibboel
Oct 28, 2014·Frontiers in Cellular Neuroscience·Nicolas Stifani
Jun 26, 2015·Physiological Reviews·Lionel A TintignacMarkus A Rüegg
Jan 17, 2020·ELife·Alicia N VagnozziPolyxeni Philippidou
Mar 23, 1999·Journal of Neurophysiology·M Martin-Caraballo, J J Greer
Feb 5, 2000·Journal of Applied Physiology·M Martin-CaraballoJ J Greer
Jun 10, 2000·Journal of Neurophysiology·M Martin-Caraballo, J J Greer
Jun 16, 2001·Journal of Applied Physiology·K KobayashiJ J Greer
Mar 6, 1999·Journal of Applied Physiology·J J GreerR P Lemke
Sep 6, 2001·Journal of Neurophysiology·R L AndersonI L Gibbins
Mar 2, 2013·Journal of Anatomy·Tatsuya Hirasawa, Shigeru Kuratani
Aug 2, 2017·Neural Regeneration Research·Michael George Zaki Ghali
Apr 30, 1999·Physiological Reviews·G Hilaire, B Duron
Oct 16, 2019·Respiratory Physiology & Neurobiology·Nina R MorrisonAdrianne G Huxtable
Aug 23, 2005·Brain Research. Brain Research Reviews·Livia CarrascalPedro A Nunez-Abades

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