Development of piriform cortex interhemispheric connections via the anterior commissure: progressive and regressive strategies

Brain Structure & Function
Eduardo Martin-LopezCharles A Greer

Abstract

The anterior commissure (AC) is a phylogenetically conserved inter-hemispheric connection found among vertebrates with bilateral symmetry. The AC connects predominantly olfactory areas but many aspects of its development and structure are unknown. To fill this gap, we investigated the embryonic and postnatal development of the AC by tracing axons with DiI and the piggyback transposon multicolor system. With this strategy, we show that axon growth during establishment of the AC follows a strictly regulated timeline of events that include waiting periods ("regressive strategies") as well as periods of active axon outgrowth ("progressive strategies"). We also provide evidence that these processes may be regulated in the midline via overexpression of chondroitin sulfate proteoglycans. Additionally, we demonstrate that the ipsi- and contralateral innervation of piriform cortex occurs simultaneously. Morphologically, we found that 20% of axons were myelinated by postnatal day (P) 22, in a process that occurred fundamentally around P14. By immunohistochemistry, we described the presence of glial cells and two new subtypes of neurons: one expressing a calretinin (CR)-/MAP2+ phenotype, distributed homogeneously inside the AC; and the ot...Continue Reading

References

Nov 1, 1979·Experimental Neurology·M L Jouandet, M S Gazzaniga
Apr 15, 1978·The Journal of Comparative Neurology·L B Haberly, J L Price
Sep 7, 1981·Brain Research·J A Horel, D J Stelzner
Jul 1, 1981·Brain Research·D Wahlsten
Aug 1, 1980·The Journal of Comparative Neurology·K A Fitzpatrick, T J Imig
Oct 10, 1997·Cell and Tissue Research·R U Margolis, R K Margolis
Dec 31, 1997·The Journal of Comparative Neurology·F ShangP M Waite
Aug 29, 1998·The Journal of Comparative Neurology·M A Pires-NetoR Lent
Oct 6, 1998·Annual Review of Biochemistry·R V Iozzo
Nov 1, 2000·The Anatomical Record·Z KaprielianE Runko
Mar 19, 2002·Brain Research·Jorge Larriva-SahdAlfredo Varela-Echavarria
Dec 10, 2002·Science·Barry J Dickson
Apr 18, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Susanna PoppRichard U Margolis
Feb 6, 2004·Brain Research. Developmental Brain Research·Kazuyo MisakiToshio Terashima
Feb 24, 2004·Molecular Biology of the Cell·Yaojiong WuBurton B Yang
May 1, 2004·Bipolar Disorders·Caleb M AdlerStephen M Strakowski
Feb 9, 2005·The Journal of Comparative Neurology·Roberto LentCathérine Fallet
Feb 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jiangyang ZhangSusumu Mori
Mar 22, 2005·Nature Neuroscience·Fadel TissirAndre M Goffinet
Apr 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fumikazu SutoHajime Fujisawa
Apr 26, 2005·Neuron·Christine E Holt, Barry J Dickson
May 14, 2005·The Journal of Comparative Neurology·Chikako KudoKazunori Nakajima
Nov 29, 2005·Developmental Biology·Shubha ToleJean M Hébert
Dec 31, 2005·The Journal of Comparative Neurology·Daniel-Robert ChebatMaurice Ptito
Nov 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rosalind S E CarneyJoshua G Corbin
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lei ChenChia-Yi Kuan
Sep 20, 2007·Cerebral Cortex·Fernando García-MorenoJuan A de Carlos
Aug 16, 2008·The European Journal of Neuroscience·Hidetoshi KassaiAtsu Aiba

❮ Previous
Next ❯

Citations

Apr 14, 2019·Scientific Reports·Carolien G F de Kovel, Clyde Francks
May 8, 2021·Seminars in Cell & Developmental Biology·Laura R FenlonLinda J Richards

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases
electron microscopy

Software Mentioned

MorphoLibJ
Fiji Analyze Particles
Fiji ( ImageJ
Statistica

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
R Lent, R Z Guimarães
Sheng li ke xue jin zhan [Progress in physiology]
Z S Han, G Ju
Progress in Neuro-psychopharmacology & Biological Psychiatry
Eric C Dumont
© 2022 Meta ULC. All rights reserved