Development of poly(ethylene glycol) hydrogels for salivary gland tissue engineering applications

Tissue Engineering. Part a
Andrew D ShubinDanielle S W Benoit

Abstract

More than 40,000 patients are diagnosed with head and neck cancers annually in the United States with the vast majority receiving radiation therapy. Salivary glands are irreparably damaged by radiation therapy resulting in xerostomia, which severely affects patient quality of life. Cell-based therapies have shown some promise in mouse models of radiation-induced xerostomia, but they suffer from insufficient and inconsistent gland regeneration and accompanying secretory function. To aid in the development of regenerative therapies, poly(ethylene glycol) hydrogels were investigated for the encapsulation of primary submandibular gland (SMG) cells for tissue engineering applications. Different methods of hydrogel formation and cell preparation were examined to identify cytocompatible encapsulation conditions for SMG cells. Cell viability was much higher after thiol-ene polymerizations compared with conventional methacrylate polymerizations due to reduced membrane peroxidation and intracellular reactive oxygen species formation. In addition, the formation of multicellular microspheres before encapsulation maximized cell-cell contacts and increased viability of SMG cells over 14-day culture periods. Thiol-ene hydrogel-encapsulated mi...Continue Reading

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Citations

Feb 16, 2016·Biomaterials Science·Tugba OzdemirXinqiao Jia
Jan 18, 2017·Journal of Biomedical Materials Research. Part a·Kanika VatsDanielle S W Benoit
Jan 4, 2017·Journal of Dental Research·H S ShinJ Y Lim
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Jan 5, 2020·Cell and Tissue Research·Andrew D ShubinCatherine E Ovitt
Aug 25, 2020·Tissue Engineering. Part a·Caitlynn M L BarrowsSimon Young
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Methods Mentioned

BETA
MDA
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Software Mentioned

Prism
ImageJ
VisioPharm

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