DOI: 10.1101/19009647Oct 18, 2019Paper

Development of population and Bayesian models for applied use in patients receiving cefepime

MedRxiv : the Preprint Server for Health Sciences
Jiajun LiuMarc H Scheetz


Understanding exposures of cefepime, a {beta}-lactam antibiotic, is crucial for developing regimens to achieve optimal exposure and improved clinical outcomes. This study sought to develop and evaluate a unified population pharmacokinetic model in both pediatric and adult patients receiving cefepime treatment. Multiple physiologically relevant models were fit to pediatric and adult subject data. To evaluate the final model performance, a withheld group of twelve pediatric and two separate adult populations were assessed. Seventy subjects with a total of 604 cefepime concentrations were included in this study. All adults (n=34) on average weighed 82.7 kg and displayed a mean creatinine clearance (CrCL) of 106.7 mL/min. All pediatric subjects (n=36) had mean weight and CrCL of 16.0 kg and 195.64 mL/min, respectively. A covariate-adjusted two compartment model described the observed concentrations well (population model R2, 87.0%; Bayesian model R2, 96.5%). In the evaluation subsets, the model performed similarly well (population R2, 84.0%; Bayesian R2, 90.2%). The identified model serves well for population dosing and as a Bayesian prior for precision dosing.

Related Concepts

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

The Lancet Infectious Diseases
Jeroen MebisZwi Nisan Berneman
Journal of Clinical Pharmacy and Therapeutics
V Lima-RogelS Romano-Moreno
Journal of Pharmacology & Pharmacotherapeutics
Mossad Gamaleddin Ahmed ElsayedMohamed Elbadawy
© 2021 Meta ULC. All rights reserved