Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime.

Clinical Pharmacokinetics
Jiajun LiuMarc H Scheetz

Abstract

Understanding pharmacokinetic disposition of cefepime, a β-lactam antibiotic, is crucial for developing regimens to achieve optimal exposure and improved clinical outcomes. This study sought to develop and evaluate a unified population pharmacokinetic model in both pediatric and adult patients receiving cefepime treatment. Multiple physiologically relevant models were fit to pediatric and adult subject data. To evaluate the final model performance, a withheld group of 12 pediatric patients and two separate adult populations were assessed. Seventy subjects with a total of 604 cefepime concentrations were included in this study. All adults (n = 34) on average weighed 82.7 kg and displayed a mean creatinine clearance of 106.7 mL/min. All pediatric subjects (n = 36) had mean weight and creatinine clearance of 16.0 kg and 195.6 mL/min, respectively. A covariate-adjusted two-compartment model described the observed concentrations well (population model R2, 87.0%; Bayesian model R2, 96.5%). In the evaluation subsets, the model performed similarly well (population R2, 84.0%; Bayesian R2, 90.2%). The identified model serves well for population dosing and as a Bayesian prior for precision dosing.

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Oct 1, 1990·Antimicrobial Agents and Chemotherapy·J M KovarikJ Verhoef
Aug 1, 1993·Clinical Pharmacokinetics·M P OkamotoA Bedikian
Aug 1, 1997·Antimicrobial Agents and Chemotherapy·M D ReedJ L Blumer
Feb 10, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W A Craig
May 23, 2003·Antimicrobial Agents and Chemotherapy·Vincent H TamMichael J Rybak
Dec 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul G AmbroseGeorge L Drusano
Oct 17, 2007·Antimicrobial Agents and Chemotherapy·Sunil V BhatDavid L Paterson
Apr 10, 2008·International Journal of Clinical Pharmacology and Therapeutics·B GeorgesS Saivin
Dec 30, 2009·Antimicrobial Agents and Chemotherapy·Jared L CrandonDavid P Nicolau
Mar 20, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Wieneke Marleen MichelsRaymond Theodorus Krediet
Jan 17, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jason A RobertsUNKNOWN DALI Study
Mar 25, 2015·Diagnostic Microbiology and Infectious Disease·Nathaniel J RhodesMarc H Scheetz
Jul 1, 2015·Antimicrobial Agents and Chemotherapy·Fekade Bruck SimeJason A Roberts
Dec 17, 2015·Antimicrobial Agents and Chemotherapy·Nathaniel J RhodesMarc H Scheetz
Dec 30, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Nathaniel J RhodesMarc H Scheetz
Dec 3, 2016·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshiko YamashitaSatoshi Yamamoto
Jan 24, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T HuwylerA Huttner
Oct 27, 2017·Open Forum Infectious Diseases·Ayesha A AppaPaul S Pottinger
May 8, 2018·Health Affairs·Geoffrey S Ginsburg, Kathryn A Phillips

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Citations

Jul 1, 2020·Antimicrobial Agents and Chemotherapy·Mohammad H Al-ShaerCharles A Peloquin
Apr 23, 2021·Therapeutic Drug Monitoring·Sylvain GoutelleArnaud Friggeri

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