Development of porous HAp and β-TCP scaffolds by starch consolidation with foaming method and drug-chitosan bilayered scaffold based drug delivery system.

Journal of Materials Science. Materials in Medicine
B KunduD Basu

Abstract

The inability to maintain high concentrations of antibiotic at the site of infection for an extended period of time along with dead space management is still the driving challenge in treatment of osteomyelitis. Porous bioactive ceramics such as hydroxyapatite (HAp) and beta-tri calcium phosphate (β-TCP) were some of the alternatives to be used as local drug delivery system. However, high porosity and high interconnectivity of pores in the scaffolds play a pivotal role in the drug release and bone resorption. Ceftriaxone is a cephalosporin that has lost its clinical popularity. But has recently been reported to exhibit better bactericidal activity in vitro and reduced probability of resistance development, in combination with sulbactam, a β-lactamase inhibitor. In this article, a novel approach of forming HAp and pure β-TCP based porous scaffolds by applying together starch consolidation with foaming method was used. For the purpose, pure HAp and β-TCP were prepared in the laboratory and after thorough characterization (including XRD, FTIR, particle size distribution, etc.) the powders were used for scaffold fabrication. The ability of these scaffolds to release drugs suitably for osteomyelitis was studied in vitro. The results ...Continue Reading

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Citations

Dec 28, 2011·Journal of Materials Science. Materials in Medicine·Javier AragónDavide Viterbo
Jul 13, 2011·International Journal of Molecular Sciences·Jyoti Prakash MaityChien-Cheng Chen
Jan 12, 2011·Expert Opinion on Biological Therapy·Ting Ting Lau, Dong-An Wang
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Aug 1, 2015·Therapeutic Delivery·Jessica Amber JenningsJoel David Bumgardner
Sep 6, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Chidambaram SoundrapandianDebebrata Basu
Dec 15, 2015·BMC Surgery·Mehmet IsyarMahir Mahirogullari
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Sep 2, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Surajit MistryMathew Joy
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Apr 25, 2019·Journal of Biomaterials Applications·Joanna Mastalska-PopławskaZuzanna Góral
Jul 11, 2020·Critical Reviews in Food Science and Nutrition·Dayang Norlaila Hj LatipAbd Karim Alias
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Nov 11, 2021·Drug Delivery·Reem Khaled WassifSeham A Elkheshen

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