Development of potent inhibitors for strigolactone receptor DWARF 14.

Chemical Communications : Chem Comm
Masahiko YoshimuraShinya Hagihara

Abstract

Strigolactones (SLs) are plant hormones that suppress shoot branching through perception by their receptor protein DWARF 14 (D14). The artificial regulation of SL signaling has been considered a potent agricultural technique because plant architecture is strongly related to crop yield. In this communication, we describe the development of a small-molecule D14 inhibitor that functions at sub-micromolar levels. This potent inhibitor may be a lead compound for a first-in-class plant growth regulator.

References

Feb 20, 2007·The Plant Cell·José Antonio Aguilar-MartínezPilar Cubas
Aug 12, 2008·Nature·Mikihisa UmeharaShinjiro Yamaguchi
Aug 12, 2008·Nature·Victoria Gomez-RoldanSoizic F Rochange
Jun 23, 2009·Plant & Cell Physiology·Tomotsugu AriteJunko Kyozuka
Dec 15, 2010·Current Opinion in Plant Biology·Yonghong Wang, Jiayang Li
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·David C NelsonSteven M Smith
Nov 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Javier AgustiThomas Greb
Dec 4, 2012·Molecular Plant·Binne Zwanenburg, Tomás Pospísil
May 17, 2015·Plant Physiology·Hiroaki Ueda, Makoto Kusaba
Apr 3, 2016·Bioorganic & Medicinal Chemistry Letters·Claudio ScrepantiAlain De Mesmaeker
Jun 29, 2017·The Journal of Physical Chemistry. B·Fang-Yu Lin, Alexander D MacKerell
Mar 14, 2018·ACS Central Science·Masahiko YoshimuraShinya Hagihara
Aug 20, 2016·Journal of Pesticide Science·Okishi MashitaTadao Asami
Jul 10, 2019·Angewandte Chemie·Harro J BouwmeesterAlain De Mesmaeker

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BETA
genetic modifications

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