Development of Predictive Value of Urinary Cytokine Profile Induced During Intravesical Bacillus Calmette-Guérin Instillations for Bladder Cancer

Clinical Genitourinary Cancer
Jérôme RigaudEmmanuel Scotet

Abstract

We sought to demonstrate a correlation between the response to treatment and the profile of urinary cytokine production during bacillus Calmette-Guérin (BCG) therapy. From December 2008 to February 2011, 23 patients were included in a prospective study. All patients received 6 instillations of BCG weekly. The mean follow-up period of the population was 16.9 ± 8.4 months. Refractory disease or recurrence was observed in 5 patients. Urine samples were collected and stored at -80°C, before and 4 hours after the first, third, and sixth BCG instillations. The cytokines (interleukin [IL]-2, IL-4, IL-6, IL-10, IL-17, interferon-gamma [IFNγ] and tumor necrosis factor-alpha) were quantified within the collected urine samples using cytometric bead array analysis. The quantitative variables were analyzed using Student's t test, and regression statistical analysis was performed. Urinary cytokine production had increased strongly 4 hours after the sixth instillation but only mildly to moderately after the first and third instillations. IL-2 and IL-6 showed the most dramatic changes after the BCG instillations. Different urinary cytokine production profiles were demonstrated. A trend was observed for the BCG-refractory/recurrence group, with...Continue Reading

References

Aug 1, 1986·Clinical Immunology and Immunopathology·T L RatliffW J Catalona
Sep 25, 2003·International Journal of Cancer. Journal International Du Cancer·Fabien SaintDominique K Chopin

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Citations

Nov 29, 2015·The Urologic Clinics of North America·Aurélie MbeutchaShahrokh F Shariat
Mar 12, 2019·Current Opinion in Urology·Abhishek Bhat, Chad R Ritch

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