Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore

Bioorganic & Medicinal Chemistry Letters
L ZhiWilliam T Schrader

Abstract

A series of 1,2-dihydrochromeno[3,4-f]quinoline derivatives was synthesized and tested in biological assays to evaluate the nonsteroidal progesterone receptor modulator pharmacophore (4) as antiprogestins. A number of potent analogues were identified by modification of the substituents at the D-ring.

References

Sep 1, 1993·Bio/technology·D K McCormick, M Goodstein
Apr 1, 2000·Bioorganic & Medicinal Chemistry Letters·L ZhiT K Jones
Feb 23, 2002·Bioorganic & Medicinal Chemistry Letters·Puwen ZhangJohn Yardley
Sep 5, 2003·Journal of Medicinal Chemistry·Lin ZhiWilliam T Schrader

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Citations

Mar 18, 2004·Bioorganic & Medicinal Chemistry Letters·Steven W ElmoreBen Lane
Jun 1, 2005·Bioorganic & Medicinal Chemistry Letters·David G JonesWilliam J Hoekstra
Sep 22, 2015·Journal of Medicinal Chemistry·Peter I Dosa, Elizabeth Ambrose Amin
Jan 1, 2010·Expert Opinion on Drug Discovery·Tommi H Nyrönen, Annu A Söderholm
Oct 3, 2006·Medicinal Research Reviews·Kevin P MadaussShawn P Williams
Feb 27, 2019·Chemistry : a European Journal·Masanori ShigenoYoshinori Kondo

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