Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41

Viruses
Jing PuShibo Jiang

Abstract

Application of highly active antiretroviral drugs (ARDs) effectively reduces morbidity and mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant strains has led to the increased failure of ARDs, thus calling for the development of anti-HIV drugs with targets or mechanisms of action different from those of the current ARDs. The first peptide-based HIV entry inhibitor, enfuvirtide, was approved by the U.S. FDA in 2003 for treatment of HIV/AIDS patients who have failed to respond to the current ARDs, which has stimulated the development of several series of protein- and peptide-based HIV entry inhibitors in preclinical and clinical studies. In this review, we highlighted the properties and mechanisms of action for those promising protein- and peptide-based HIV entry inhibitors targeting the HIV-1 gp120 or gp41 and discussed their advantages and disadvantages, compared with the current ARDs.

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Citations

Aug 31, 2020·The Journal of Membrane Biology·Gourab Prasad Pattnaik, Hirak Chakraborty
Jan 28, 2021·Microorganisms·Jean-François BruxelleRalph Pantophlet
Feb 4, 2021·Cellular and Molecular Life Sciences : CMLS·Yuxin FuOscar P Kuipers
May 1, 2021·Viruses·Tianshu XiaoBing Chen
Jul 14, 2021·Bioconjugate Chemistry·Maria J GómaraIsabel Haro
Oct 5, 2021·Chembiochem : a European Journal of Chemical Biology·Susanne HuhmannBeate Koksch

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Methods Mentioned

BETA
phage display
glycosylation
two-hybrid

Software Mentioned

Trimeris

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