Development of quercetin nanoformulation and in vivo evaluation using streptozotocin induced diabetic rat model

Drug Delivery and Translational Research
Deepak ChitkaraNeeraj Kumar

Abstract

Quercetin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Qu-NP) were prepared by emulsion-diffusion-evaporation method and characterized as 179.9 ± 11.2 nm in size with 0.128 as polydispersity index, more than 86% drug entrapment efficiency, and zeta potential was -6.06 ± 1.51 mV. D-Trehalose (5% w/v) was found to be a suitable cryoprotectant for lyophilization of Qu-NP, and antioxidant assays indicated that Qu-NP were able to retain the antioxidant property similar to that of free drug at equivalent concentration after formulation development. In vitro release study of Qu-NP showed a controlled release pattern of quercetin. An enhanced oral bioavailability (523% relative increase) was observed in pharmacokinetic study with a 6-day sustained release from Qu-NP as compared to quercetin suspension, which indicated the reduced dosing frequency. Efficacy in diabetic rats suggested that same dose of Qu-NP on every fifth day was sufficient to bring effect similar to daily dose of oral quercetin suspension, and the same effect was also observed for catalase and superoxide dismutase levels in pancreas and kidneys. Thus, the system offers an efficacious oral therapy with reduced dose and dosing frequency for treatment of dia...Continue Reading

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Citations

Jun 13, 2013·Pharmaceutical Research·Deepak Chitkara, Neeraj Kumar
Mar 20, 2015·Drug Delivery and Translational Research·Deepak ChitkaraNeeraj Kumar
Nov 5, 2016·Colloids and Surfaces. B, Biointerfaces·Dongdong SunWeiyun Wang
Oct 21, 2016·Journal of Liposome Research·Jin RenQian Du
Nov 16, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hao Thanh Nguyen, Francisco M Goycoolea
Jan 13, 2018·Bioscience, Biotechnology, and Biochemistry·Zhen LuGuangxi Zhai
Mar 27, 2020·International Journal of Molecular Sciences·Saikat DewanjeeVincenzo De Feo
Jan 31, 2020·Frontiers in Bioengineering and Biotechnology·Alexander VaisermanOleh Lushchak
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Nov 7, 2019·GeroScience·Oleh LushchakAlexander Vaiserman
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Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monika BhardwajSudhir Kumar Kataria
Jul 7, 2021·Journal of Biomaterials Science. Polymer Edition·Rakesh Kumar PaulKaisar Raza
Jul 8, 2020·Journal of Agricultural and Food Chemistry·Zeynep GoktasShu Wang
Oct 8, 2021·Environmental Science and Pollution Research International·Rahul TripathiPravir Kumar

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