PMID: 11321284Apr 26, 2001Paper

Development of reactive onchocercal skin lesions during a placebo-controlled trial with ivermectin among persons without lesions at baseline

Tropical Doctor
W R BriegerO O Ososanya

Abstract

Clinical trials of the effects of ivermectin on onchocercal skin disease have documented reduction in itching, but a less than clear benefit on reactive skin lesions. It has been suggested that one of the positive effects might be the prevention of new lesions. A study among a rural adult farming population in southwestern Nigeria provided ivermectin in three treatment groups and a placebo to community members who were examined and treated at 3-monthly intervals over a 15-month period. Among the 1206 people recruited for the study, 627 (52%) had no lesions at baseline examination. Atotal of 291 participants without baseline lesions attended all five follow-up examinations, and only their results were analysed. Members of all four groups developed new lesions, but those receiving ivermectin had a consistently lower proportion of lesions than the placebo group. This difference reached statistical significance at the 5% level in three of the five periods and was below the 10% level at the other two periods. These findings are suggestive of an inhibiting effect of ivermectin among those without lesions at the beginning of a community treatment programme, and justify community treatment as a way of limiting morbidity and social stig...Continue Reading

References

May 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·J A WhitworthD W Taylor
Sep 1, 1993·The British Journal of Dermatology·M E MurdochB R Jones
Sep 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·D C ChavasseJ B Davies
Jun 1, 1996·The American Journal of Tropical Medicine and Hygiene·M E MurdochR M Parkhouse
Dec 1, 1996·Tropical Medicine & International Health : TM & IH·J A WhitworthM D Downham
Jan 19, 1999·Tropical Medicine & International Health : TM & IH·W R BriegerJ H Remme

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Citations

Oct 28, 2009·PLoS Neglected Tropical Diseases·Joan Muela RiberaSusanna Hausmann-Muela
Jun 26, 2002·Annals of Tropical Medicine and Parasitology·A SékétéliK Y Dadzie
Dec 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Don N Udall

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