Development of recommendations for dosing of commonly prescribed medications in critically ill obese children

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Emma L RossPamela D Reiter

Abstract

The development and use of a decision support tool to help formulate recommendations for dosing of commonly prescribed medications in critically ill obese children are described. Medications prescribed in 2010 to critically ill infants and children (younger than 18 years) were identified from the Pediatric Health Information System. The most commonly prescribed and therapeutically monitored medications were extracted. Supportive evidence for obesity dosing was identified through a standardized computerized search involving medical subject heading terminology and age filters using PubMed and Ovid. A usefulness scoring system was developed to rate the strength and applicability of the literature to critically ill obese children. A decision supporttool was then created to aid in the formulation of a dosing weight for each medication based on the usefulness score, published pharmacokinetic properties, clinical studies available in the primary literature, and consideration of clinical consequences of underdosing or overdosing. A total of 113 medications were evaluated, and 122 discrete citations, supporting 66 medications, were reviewed. Seventy-two percent of citations had general obesity dosing information, and 13% had pediatric-s...Continue Reading

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Citations

Sep 13, 2015·Clinical Therapeutics·Jennifer G KendrickMary H H Ensom
Apr 24, 2016·Annals of Emergency Medicine·Kelly D Young, Noah C Korotzer
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Nov 5, 2020·Journal of the American College of Emergency Physicians Open·Mike Wells, Lara Goldstein
Jun 6, 2021·Irish Journal of Medical Science·Vesna MarjanovicChristian Breschan

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