Development of resistance to Trypanosoma cruzi in mice depends on a viable population of L3T4+ (CD4+) T lymphocytes.

Infection and Immunity
F G Araujo

Abstract

Mice injected with monoclonal antibody to the L3T4+ (CD4+) cell membrane surface glycoprotein of T lymphocytes and immunized with antigens of Trypanosoma cruzi had reduced antibody and cell-mediated immune responses to the organism. Mortality in these mice was 100% following challenge with 1.5 x 10(5) trypanosomes, whereas controls had a 50% survival rate, indicating that T-cell activation and viable L3T4+ (CD4+) T lymphocytes are essential for the development of resistance.

References

Sep 1, 1988·Immunology Today·K Bottomly
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·A Ben Younès-ChennoufiM Hontebeyrie-Joskowicz
Oct 1, 1973·Experimental Parasitology·E L Roberson, W L Hanson
Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·G A SchmunisJ F Janovsky
May 1, 1984·The American Journal of Tropical Medicine and Hygiene·F G Araujo, D Guptill
Jul 1, 1985·Parasitology Today·F Kierszenbaum
Jul 1, 1985·Parasitology Today·L Hudson

❮ Previous
Next ❯

Citations

Aug 17, 2002·Infection and Immunity·Anita R SchnappDaniel F Hoft
Jul 20, 2012·Clinical & Developmental Immunology·Denise Bertulucci Rocha RodriguesVirmondes Rodrigues
Sep 1, 1992·Revista Do Instituto De Medicina Tropical De São Paulo·S GeaE Vottero-Cima
Feb 1, 1995·Scandinavian Journal of Immunology·M E RottenbergA Orn
Aug 1, 1992·Scandinavian Journal of Immunology·M E RottenbergA Orn
Nov 5, 2002·Annual Review of Immunology·Phillip Wong, Eric G Pamer
Aug 9, 2003·DNA and Cell Biology·David A Brake
Aug 12, 2014·Mediators of Inflammation·José M ÁlvarezMaria Regina D'Império Lima
Apr 1, 1998·Clinical and Diagnostic Laboratory Immunology·L VerinaudI J Camargo
Jan 1, 1995·Infection and Immunity·R A WrightsmanJ E Manning
Aug 1, 1991·Experimental Parasitology·M E RottenbergE L Segura

❮ Previous
Next ❯