Development of risk factor-based scoring system for detection of hypervirulent Klebsiella pneumoniae bloodstream infections

Gut Pathogens
Atsushi TogawaYasushi Takamatsu

Abstract

Hypervirulent Klebsiella pneumoniae (HVKp) infections have distinct clinical manifestations from classical K. pneumoniae infections. The hallmark of HVKp infections are liver abscess formation and metastatic infections. Due to the severe sequelae of these complications, method to identify patients at-risk of HVKp infections should be developed. A retrospective cohort study of 222 patients with K. pneumoniae bloodstream infections (BSIs) was performed. Patient demographics, clinical manifestations, and bacterial characteristics were investigated. Ten cases of liver abscesses were identified. Characteristics such as community-onset BSIs, hypermucoviscosity phenotype, and capsular serotype K1 were identified as risk factors for HVKp infections. A scoring system was developed based on the risk factors. The area under the receiver operating characteristic curve for the scoring system was 0.90. A score of ≥ 2 points provided sensitivity and specificity of 0.70 and 0.94, respectively. Simple scoring system was developed for the diagnosis of HVKp infections. The system allows early identification of patients with K. pneumoniae BSIs in whom hypervirulent infections should be evaluated. Prospective evaluation is expected.

References

Apr 1, 1976·Journal of Clinical Pathology·E RiserT A Poulton
Oct 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B S HuY H Lin
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Saccente
Feb 3, 2006·The Journal of Infectious Diseases·Yi-Ping ChuangJin-Town Wang
Apr 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wen-Liang YuYin-Ching Chuang
Jun 30, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chi-Tai FangShan-Chwen Chang
Apr 5, 2011·Radiology·Hind S AlsaifSophia Archuleta
Oct 27, 2012·The Lancet Infectious Diseases·L Kristopher SiuFeng-Yee Chang
Jun 17, 2016·Microbiology and Molecular Biology Reviews : MMBR·Michelle K Paczosa, Joan Mecsas
Mar 31, 2017·Clinical Microbiology Reviews·Marlene L Durand
Apr 14, 2017·Virulence·Juan Carlos Catalán-NájeraHumberto Barrios-Camacho
Dec 15, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jiayang LiJieshou Li

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Citations

Mar 12, 2021·Clinical Microbiology Reviews·Caitlyn L HolmesMichael A Bachman
Aug 5, 2021·QJM : Monthly Journal of the Association of Physicians·Ryohei Ono, Izumi Kitagawa

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BETA
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