Development of Secondary Osteosarcoma After TBI and Allogeneic Bone Marrow Transplant: A Case Series of 3 Patients

Journal of Pediatric Hematology/oncology
Amanda ScheuermannMeghen Browning

Abstract

Osteosarcoma can rarely occur as a subsequent malignant neoplasm after cancer therapy. Children who underwent treatment for cancer and received an allogeneic hematopoietic cell transplant are at a higher risk to develop secondary malignancies. Radiation is also a known risk factor, but estimating the quantitative risk is difficult due to the rarity of the condition and long latency period between primary and secondary cancer. In this report, we present 3 patients diagnosed with leukemia as young children who received hematopoietic cell transplants with total body irradiation as part of the conditioning regimen, and later went on to develop secondary osteosarcoma.

References

Apr 20, 2001·Journal of the National Cancer Institute·J P NegliaL L Robison
Apr 19, 2006·International Journal of Radiation Oncology, Biology, Physics·Eric J Hall
Aug 15, 2006·Clinical Orthopaedics and Related Research·Mahmood ShaheenJay S Wunder
Aug 19, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Uwe SchneiderBeate Timmermann
Oct 31, 2008·Blood·J Douglas RizzoH Joachim Deeg
Feb 10, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Maurice Tubiana
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anna T MeadowsPeter D Inskip
Dec 8, 2009·Upsala Journal of Medical Sciences·Atsushi OkadaEiji Itoi
Jan 18, 2011·Hematology·Mohamad Mohty, Jane F Apperley
May 17, 2012·Clinical Sarcoma Research·Yulia A SavitskayaJosé Clemente Ibarra-Ponce de León
Jul 17, 2012·International Journal of Radiation Oncology, Biology, Physics·Tara O HendersonLisa Diller
Oct 6, 2012·Clinical Sarcoma Research·Amy Berrington de GonzalezPreetha Rajaraman
Dec 20, 2012·International Journal of Environmental Research and Public Health·Sanath Kumar
Jul 17, 2015·BioMed Research International·Weicong RenJuan Li
Mar 15, 2016·International Journal of Radiation Oncology, Biology, Physics·Peter D InskipJoseph P Neglia
Mar 1, 2017·JAMA : the Journal of the American Medical Association·Lucie M TurcotteJoseph P Neglia
May 4, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Lynda M VroomanChristine Duncan

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Citations

Jun 4, 2020·Journal of Adolescent and Young Adult Oncology·Marta PierobonGianni Bisogno

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Methods Mentioned

BETA
biopsy
surgical resection

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