Development of self-assembling peptide nanovesicle with bilayers for enhanced EGFR-targeted drug and gene delivery

Biomaterials
Xiaofei LiangZonghai Li

Abstract

Development of rational vectors for efficient drug and gene delivery is crucial for cancer treatment. In this study, epidermal growth factor receptor (EGFR)-binding peptide amphiphile (PA) were used as the primary bilayer skeleton material to construct ultra-stable self-assembling peptide nanovesicle (SPV). The resulted EGFR-targeted SPV (ESPV) could efficiently encapsulate therapeutic cargos (drugs or small interfering RNAs [siRNAs]) or labelled fluorescent cargo (quantum dots [QDs]) and exhibited excellent affinity for EGFR-positive cancer cells. Moreover, ESPV could deliver more drug or plasmid DNA to tumour sites and promote gene expression (a three-fold ratio of ESPVs vs cationic liposomes). Notably, the individual delivery or co-delivery of doxorubicin (DOX) and the acetylcholinesterase (AChE) gene via the ESPVs resulted in excellent drug/gene delivery both in vitro and in vivo and exerted a significant growth-suppressing effect on a liver cancer xenograft. This nanoscale, targeted cargo-packaging technology may provide a new strategy for the design of highly targeted cancer therapy vectors.

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Citations

Aug 19, 2016·Advanced Drug Delivery Reviews·Handan AcarMatthew Tirrell
Aug 20, 2016·Advanced Drug Delivery Reviews·Huihui KuangEfrosini Kokkoli
Jan 19, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Sijia WangHonglai Liu
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Apr 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chen-Yang ZhaoZhong-Min Tian
Sep 12, 2020·Nanomedicine·Neha MehrotraHarpal Singh
Sep 12, 2019·Biomaterials Science·Qian WangJianfeng Liu
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Nov 17, 2020·Frontiers in Chemistry·Tuerdimaimaiti AbudulaSidi A Bencherif
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Jul 8, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Reza MohammadinejadAli Zarrabi
Mar 30, 2021·ACS Biomaterials Science & Engineering·Sofia PeressottiRylie A Green
Nov 18, 2017·ACS Applied Materials & Interfaces·Yun-Xia SunXian-Zheng Zhang
Apr 10, 2019·Journal of the American Chemical Society·Quanbing MouChuan Zhang
Apr 4, 2020·ACS Applied Materials & Interfaces·Xuelin XiaDeyue Yan
Sep 22, 2021·Journal of Biomedical Nanotechnology·Chuanguang XiaoWenyue Gu
Sep 28, 2021·International Journal of Pharmaceutics·Phuoc Vinh NguyenEmilie Allard-Vannier

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