Development of SNP-based human identification system.

International Journal of Legal Medicine
Jae-Jung KimJong-Keuk Lee

Abstract

Single nucleotide polymorphisms (SNPs) appeal to the forensic DNA community because of their abundance in the human genome, low mutation rate, small amplicon size, and feasibility of high-throughput genotyping technologies.In an initial screening, we identified six SNP markers of sex determination by resequencing the amelogenin genes and the zinc finger protein genes located on the sex chromosomes. Furthermore, for use in human identification,we selected 30 highly polymorphic autosomal SNP markers from among a human population and examined the potential utility of these SNP markers for human identification.The combined mean match probability of 30 SNP markers was 4.83 x 10(-13). Using genotyping data from 8,842 unrelated Korean individuals, we also found that discrimination power increased 10-fold for the addition of every five SNP markers in human identification. In this study, we demonstrated that SNP markers are very useful for sex determination and human identification, even in a very homogeneous population.

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Citations

Mar 10, 2011·Nanomedicine·Emiliano GiardinaGiuseppe Novelli
Jul 24, 2010·International Journal of Legal Medicine·Christoph G BirngruberMarcel A Verhoff
Jun 3, 2015·American Journal of Primatology·Anja WiddigJörg Schmidtke
Aug 25, 2015·International Journal of Legal Medicine·Hsiao-Lin HwaJames Chun-I Lee
Jun 15, 2011·Journal of Forensic and Legal Medicine·B C ManjunathR M Vatchala Rani
Oct 27, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Qingqing DuBin Cong
Apr 28, 2012·Journal of Forensic Sciences·Yi-Liang WeiYao Liu
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Dec 16, 2017·Planta·Jose Antonio Garrido-CardenasFrancisco Manzano-Agugliaro
Jan 27, 2020·Molecular Biology Reports·Hirak R DashSurajit Das
Mar 21, 2020·Iranian Journal of Biotechnology·Sajad HabibiMahmood Tavallaie
Apr 29, 2021·International Journal of Legal Medicine·Soyeon BaeHeebal Kim
May 3, 2011·Analytical Chemistry·T A BrettellJ R Almirall

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