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Development of SPECT Probes for In Vivo Imaging of β-Amyloid and Tau Aggregates in the Alzheimer's Disease Brain

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

Nov 3, 2017

Hiroyuki Watanabe

Abstract

Alzheimer's disease (AD) is the most common form of irreversible dementia among elderly people. In the postmortem brains of AD patients, the deposition of senile plaques composed of β-amyloid (Aβ) peptides and neurofibrillary tangles composed of highly phosphorylated tau proteins are tw...read more

Mentioned in this Paper

Drug Development
Study
Familial Alzheimer Disease (FAD)
In Vivo
Bioassay, In Vivo
Tomography, Emission-Computed, Single-Photon
APP protein, human
Positron-Emission Tomography
Heterocyclic Compounds, 3-Ring
Neurofibrillary Degeneration (Morphologic Abnormality)
Paper Details
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Development of SPECT Probes for In Vivo Imaging of β-Amyloid and Tau Aggregates in the Alzheimer's Disease Brain

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

Nov 3, 2017

Hiroyuki Watanabe

PMID: 29093372

DOI: 10.1248/yakushi.17-00156

Abstract

Alzheimer's disease (AD) is the most common form of irreversible dementia among elderly people. In the postmortem brains of AD patients, the deposition of senile plaques composed of β-amyloid (Aβ) peptides and neurofibrillary tangles composed of highly phosphorylated tau proteins are tw...read more

Mentioned in this Paper

Drug Development
Study
Familial Alzheimer Disease (FAD)
In Vivo
Bioassay, In Vivo
Tomography, Emission-Computed, Single-Photon
APP protein, human
Positron-Emission Tomography
Heterocyclic Compounds, 3-Ring
Neurofibrillary Degeneration (Morphologic Abnormality)

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Paper Details
References
  • References16
  • Citations
12
  • References16
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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