Development of sustained-release tablets containing sodium valproate: in vitro and in vivo correlation

Drug Development and Industrial Pharmacy
Yuki FujisakiKenji Sugibayashi

Abstract

We have developed a 200 mg and 400 mg sustained-release sodium valproate tablet that allows effective blood concentration of the active drug with once-a-day dosing. The controlled dissolution or sustained release of the drug was attained by a membrane-controlled system. A single-coating system did not adequately control the dissolution rate, and therefore double-coated tablets were prepared and a human pharmacokinetic study was conducted. With the 200 mg VPA-Na tablets, the nonfasting C(max) was only 20% higher than the fasting C(max). An in vitro dissolution test was conducted to predict the effects of food on drug dissolution after administration of this tablet. A relatively good correlation was observed between the absorption profiles and the dissolution profiles of the drug.

References

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Jun 1, 1992·Journal of Pharmaceutical Sciences·V P ShahJ P Skelly
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Citations

May 3, 2007·Psychiatry and Clinical Neurosciences·Norio Yasui-FurukoriSunao Kaneko
Nov 19, 2009·Drug Design, Development and Therapy·Akira FujiiSunao Kaneko
Sep 15, 2010·Indian Journal of Pharmaceutical Sciences·T PhaechamudS Chitrattha
Apr 14, 2017·CNS Drugs·Peer Tfelt-HansenJacob Tfelt-Hansen

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