Development of synapses and expression of a voltage-gated potassium channel in chick embryonic auditory nuclei

Hearing Research
Jane J Feng, D K Morest

Abstract

The potassium channel protein, Kv3.1, is abundantly expressed in the chick auditory pathway. Its b-isoform is found in nucleus magnocellularis, which receives the cochlear input, both before and after the establishment of synaptic connections. It is also present in cell cultures in the absence of any peripheral input. However, the expression of this isoform in the embryo has been shown to increase with development. Here, we address the question of the correlation between maturation of synapses in the auditory pathway and the pattern of expression of the b-isoform in a series of embryos prepared for immunohistochemistry at Hamburger-Hamilton stages equivalent to E10, E12, E14, and E17. We show here that this subunit translocates from the perinuclear cytoplasm to the cell membrane domain in nucleus magnocellularis at the time that cochlear nerve endings emerge as endbulbs of Held (E17). In nucleus laminaris, by this time, while abundant Kv3.1b occurs in the perinuclear cytoplasm, a translocation to the cell membrane domain has not yet occurred, and the mature peri-synaptic localization is delayed to a later stage. This difference suggests a hierarchy in the developmental expression of Kv3.1. An unexpected finding is the expressio...Continue Reading

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Citations

Sep 14, 2011·Journal of Molecular Neuroscience : MN·Enrica BodaFilippo Tempia
Nov 24, 2011·Journal of Neuroscience Research·J FengD K Morest
Jul 18, 2009·Journal of Neuroscience Research·J FengD K Morest
Sep 15, 2017·Physiological Reviews·Leonard K Kaczmarek, Yalan Zhang
May 24, 2008·Developmental Neurobiology·Matthew J Korn, Karina S Cramer
Jul 30, 2019·Annals of Clinical and Translational Neurology·Jillian M CameronSamuel F Berkovic
Oct 20, 2017·Journal of Neurophysiology·Briana J CarrollRichard L Hyson

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