Abstract
Asthma is characterized by chronic inflammation of large and small airways maintained by extravasation of leukocytes from the bloodstream into the surrounding peribronchial tissue. The process of extravasation is of crucial importance in inflammation and is mediated by a sequenced and concerted action between different adhesion molecules on endothelial cells and ligands on leukocytes. In this context, initial rolling and tethering is generally considered to be the primary event which is mediated by selectins, a family of glycoproteins comprised of E-, P- and L-selectin. Their role in asthma has been demonstrated in a variety of animal models, showing that all three selectins are involved in the chronic inflammation in asthma. Therefore, selectins are an attractive target where pan-selectin antagonism is the desired treatment strategy. Here, we give an overview of the status of the preclinical and clinical development of bimosiamose, the most advanced synthetic pan-selectin antagonist as a treatment for asthma.
Citations
Dec 4, 2003·European Journal of Pharmacology·Yasuyuki OnaiMitsuaki Isobe
Dec 5, 2003·Trends in Pharmacological Sciences·Holger UlbrichLennart Lindbom
Apr 2, 2005·Biological & Pharmaceutical Bulletin·Holger UlbrichGerd Dannhardt
Aug 2, 2007·Expert Opinion on Therapeutic Targets·Ralf J LudwigWolf-Henning Boehncke
Jul 25, 2006·Expert Opinion on Investigational Drugs·Daniel BockGerhard Wolff
Sep 19, 2007·Biopharmaceutics & Drug Disposition·Michael MeyerGerhard Wolff
Oct 28, 2006·British Journal of Clinical Pharmacology·Michael MeyerGerhard Wolff
Sep 6, 2005·Pulmonary Pharmacology & Therapeutics·Kai M BeehGerhard Wolff
Oct 12, 2004·Immunology and Allergy Clinics of North America·Bruce S Bochner
Nov 1, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T TanriverdiM Y Kaynar
Oct 22, 2009·Chemical Biology & Drug Design·Huahui ZengHuabei Zhang
Apr 9, 2005·Treatments in Respiratory Medicine·Suzanne J Romano
Jun 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Igor TvaroškaJaroslav Koča
Mar 19, 2008·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Darren G Woodside, Peter Vanderslice
Apr 21, 2006·Kidney International·C JayleT Hauet
Feb 17, 2007·Journal of Medicinal Chemistry·Remo KranichEwald M Aydt
Oct 24, 2006·Drug Discovery Today·Carsten KneuerUdo Bakowsky
Sep 3, 2021·International Journal of Nanomedicine·Qiqi FengHaimei Zhu