PMID: 2114172Jun 27, 1990Paper

Development of system B0,+ and a broad-scope Na(+)-dependent transporter of zwitterionic amino acids in preimplantation mouse conceptuses

Biochimica Et Biophysica Acta
L J Van WinkleB H Farrington

Abstract

The nature and ontogeny of Na(+)-dependent L-alanine transport was examined in mouse eggs and preimplantation conceptuses. Mediated L-alanine uptake was not detected in fertilized or unfertilized eggs, but a small amount of Na(+)-dependent L-alanine transport was detected in 2-cell conceptuses. Na(+)-dependent alanine transport was more rapid at the 8-cell stage of development, and more than 10-fold faster in blastocysts than in 8-cell conceptuses. Analog inhibition analyses were consistent with the interpretation that L-lysine-sensitive and L-lysine-resistant components of transport were present at the 2-cell, 8-cell and blastocyst stages of development. The range of amino acids and their analogs that inhibited the most conspicuous component of alanine transport in blastocysts was consistent with the conclusion that system B0,+ is largely responsible for L-alanine uptake in these conceptuses. Moreover, system B0,+, but not other known systems in blastocysts, became susceptible to activation as these conceptuses approached the time of implantation, so this activation could be involved in implantation. Although the data are consistent with the possibility that system B0,+ is also present in 2-cell and 8-cell conceptuses, the rel...Continue Reading

References

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Citations

Jan 4, 2008·Amino Acids·M A GrilloS Colombatto
Nov 1, 1990·Developmental Biology·L J Van WinkleR L Garton
Jul 1, 1991·Developmental Biology·L J Van Winkle, A L Campione
Jul 17, 2009·Biology of Reproduction·Amélie M D PellandJay M Baltz
Feb 17, 1998·Experimental Eye Research·K HosoyaV H Lee
Jan 3, 2001·Biology of Reproduction·L J Van Winkle
Aug 2, 2013·Biology of Reproduction·Megan KooistraJay M Baltz
Jun 13, 2003·Biology of Reproduction·Patrick M MartinLon J Van Winkle
Oct 18, 2006·Journal of Cellular Physiology·Mohamed-Kheir Idris AnasJay M Baltz
Sep 1, 1993·Molecular Reproduction and Development·R S PratherL J Van Winkle
Mar 1, 1993·Molecular Reproduction and Development·R S PratherL J Van Winkle
Mar 30, 2006·American Journal of Physiology. Endocrinology and Metabolism·Robyn L O'KaneRichard A Hawkins
Sep 10, 2014·Amino Acids·Rodrigo ManjarinNathalie L Trottier
Sep 27, 2012·Molecular Reproduction and Development·Jay M Baltz, Chenxi Zhou
Apr 25, 2020·Journal of Cellular Physiology·Han ZhangJay M Baltz
Aug 23, 2003·American Journal of Physiology. Endocrinology and Metabolism·Robyn L O'Kane, Richard A Hawkins
Dec 31, 2002·Physiological Reviews·Giovanni E MannLuis Sobrevia
Jun 23, 1995·The Journal of Biological Chemistry·M M Sánchez del PinoR A Hawkins
Sep 5, 2001·The Journal of Nutrition·B P Bode
Jun 9, 2009·Development·Alina P TartiaJay M Baltz
Sep 30, 1991·Biochimica Et Biophysica Acta·L J Van WinkleA L Campione
Jun 23, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ingrid HegglandTore Syversen

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