Development of T and B cell areas in peripheral lymphoid organs of the rat

The Anatomical Record
P EikelenboomJ G Streefkerk


In the present study the early development of peripheral lymphoid organs (spleen, popliteal lymph node, mesenteric lymph node and Peyer's patches) is described in terms of homing patterns of T and B cells, demonstrated with immunohistoperoxidatic detection of characteristic membrane antigen in normal rats and with routine histology in neonatally thymectomized rats. In the first days after birth the peripheral lymphoid organs are almost exclusively populated by T cells. After neonatal thymectomy lymphocytes appear in the dome areas of Peyer's patches from four to six days after birth, in mesenteric and popliteal lymph nodes lymphocytes are found in the outer cortex from day 6 and day 8 respectively and in the marginal zone of the spleen from eight days onwards. These lymphocytes showed no membrane staining when reacted for T antigen with immunohistoperoxidatic techniques. The morphological evidence for considering Peyer's patches of rats as central inductive sites for the generation of B cells is poor. The discrepancy in the order of appearance of T and B cell (sub)populations in spleen compartments in normal ontogenetic development and lethally irradiated, stem cell reconstituted animals is discussed.


Jan 1, 1985·Cell and Tissue Research·R BrelińskaJ Jaroszewski
Sep 12, 1994·European Journal of Pharmacology·A Fernández-LópezA Pazos
Jan 1, 1983·Developmental and Comparative Immunology·B E PleschM van de Ende
Jan 1, 1990·Developmental and Comparative Immunology·E P van ReesT Sminia
Jan 27, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Guy Sainte-Marie
Mar 1, 1984·The Anatomical Record·A L GranataA Corsi
Oct 1, 1983·The Anatomical Record·T SminiaB E Plesch
Jan 1, 1987·Journal of Neuroscience Research·K D AckermanD L Felten


Feb 1, 1978·The Anatomical Record·P EikelenboomH L Langevoort
Oct 1, 1976·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G J SeymourJ S Greenspan
Jan 1, 1968·International Archives of Allergy and Applied Immunology·M D CooperR A Good
Sep 1, 1973·The Journal of Experimental Medicine·P G SpearG M Edelman
Dec 1, 1973·The Journal of Experimental Medicine·I Goldschneider, D D McGregor
Jan 1, 1973·International Archives of Allergy and Applied Immunology·P K Kalpaktsoglou, R A Good
Dec 1, 1968·The Journal of Experimental Medicine·A C Aisenberg, C Davis
Nov 1, 1971·The Journal of Pathology·J M Papadimitriou, W G Spector
Apr 1, 1972·The Journal of Experimental Medicine·D D JoelH Cottier
Jan 1, 1966·The Journal of Experimental Medicine·D V ParrottJ East
Dec 1, 1966·The Australian Journal of Experimental Biology and Medical Science·B N Jaroslow, G J Nossal
Aug 1, 1962·The Journal of Experimental Medicine·B H WAKSMANB D JANKOVIC
Jul 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·H A AZAR

Related Concepts

Cortex Bone Disorders
Adrenal Cortex Diseases
Histology Procedure
Structure of Aggregated Lymphoid Follicle of Small Intestine
Popliteal Lymph Node Group
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Viral Tumor Antigens

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.