Development of Targeted Pharmacotherapy for Cardiovascular Disease

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Yasufumi Katanasaka

Abstract

Heart and cardiovascular diseases are the leading causes of death in the world. Heart failure (HF) in particular is becoming a serious widespread medical issue, especially following various stresses such as myocardial infarction and hemodynamic overload. One pathological cardiac change in HF is left ventricular hypertrophy (LVH). LVH is associated with increased risk for HF; however, no drug therapy for LVH has yet been developed. During the development of LVH, gene expression is altered in cardiomyocytes through transcription factors, co-activators, and histone modifications. A zinc-finger protein and cardiac-specific transcription factor, GATA4, forms a large complex with functional proteins, including an intrinsic histone acetyltransferase, p300. p300 serves as a co-activator of GATA4 and is required for GATA4-dependent gene transcription. Although the p300/GATA4 pathway is involved in pathological cardiac hypertrophy, the remaining signal transduction pathways involved in pathological cardiac changes remain unclear. To identify therapeutic targets for preventing HF, GATA4-binding proteins have been analyzed, and 73 proteins were identified by tandem affinity purification and mass spectrometry. Here, we describe a receptor f...Continue Reading

References

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Citations

Jan 1, 2022·Experimental and Therapeutic Medicine·Xiaoqun ZhangYanan Zhang

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