PMID: 11926389Apr 3, 2002Paper

Development of technetium-99m-based CNS receptor ligands: have there been any advances?

European Journal of Nuclear Medicine and Molecular Imaging
B Johannsen, Hans-Jürgen Pietzsch

Abstract

By virtue of its ideal nuclear physical characteristics for routine nuclear medicine diagnostics and its ready availability, technetium-99m is of outstanding interest in the development of novel radiopharmaceuticals. The potential for the development of 99mTc-based radioligands for the study the receptor function in the central nervous system (CNS) is also well recognised despite the difficulties to be overcome. A fundamental challenge is the pharmacologically acceptable integration of the transition metal technetium, with its specific coordination chemistry, into the molecular entity of CNS receptor ligands. Conceptually, the ligand molecule can be assembled by three building blocks: a small neutral chelate unit, an organic linker that may also serve as a pharmacological modifier and a receptor-binding region derived from selective receptor antagonists. The recent introduction of novel technetium chelate units, particularly mixed-ligand complexes and low-valency organometallic compounds of technetium, provides an impetus for the further development of CNS receptor ligands. Moreover, progress in receptor pharmacology and the experience gained with positron emission tomography radiotracers have facilitated the design of numerous...Continue Reading

Citations

Jan 29, 2003·Journal of Cellular Biochemistry. Supplement·Susan Z Lever
Nov 28, 2002·Nuclear Medicine and Biology·D PapagiannopoulouE Chiotellis
Jan 27, 2004·Nuclear Medicine and Biology·Célia FernandesIsabel Santos
Jun 6, 2009·Journal of Pharmaceutical Sciences·Nicolas TournierSalvatore Cisternino
Apr 3, 2012·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·A ChiotellisM Papadopoulos
Aug 8, 2008·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Yunhang GuoBoli Liu
Jan 1, 2007·PET Clinics·Kimberly P Lindsey, S John Gatley
Dec 7, 2006·Neuroimaging Clinics of North America·Kimberly P Lindsey, S John Gatley
Feb 28, 2003·Seminars in Nuclear Medicine·Hank F KungSeok Rye Choi
Feb 22, 2005·Nuclear Medicine Communications·Sally L Pimlott
Jul 11, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Raquel GarciaHartmut Spies
May 5, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Gilles GasserNils Metzler-Nolte
Jul 4, 2012·Organic & Biomolecular Chemistry·Olivier MartinageChristophe Dugave
Feb 10, 2011·Chembiochem : a European Journal of Chemical Biology·Marie AufortChristophe Dugave
Jul 13, 2006·The Journal of Physical Chemistry. a·B SafiP Geerlings
Feb 11, 2003·Journal of Inorganic Biochemistry·Charalambos TsoukalasEfstratios Chiotellis

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