Jun 13, 2002

Development of telemetry system in the common marmoset--cardiovascular effects of astemizole and nicardipine

The Journal of Toxicological Sciences
Ikuo HoriiKeitaro Hashimoto

Abstract

The purpose of this study was to evaluate a telemetry system for examining the cardiovascular system in the conscious common marmoset. Parameters obtained were blood pressure, heart rate, respiratory rate, ECG, body temperature and locomotor activity, and these were continuously recorded on a data recorder via the telemetry system and then processed by a computerized system. Diurnal rhythms of blood pressure, heart rate, body temperature and locomotor activity were observed in this system. We studied the effects of astemizole (antihistamine) and nicardipine (Ca2+ channel blocker) on cardiovascular parameters. Astemizole at 30 mg/kg (p.o.) and at 1 to 3 mg/kg (i.v.), prolonged QT interval and induced ventricular extrasystole. Torsades de pointes occurred in one of three cases at 3 mg/kg (i.v.) and 30 mg/kg (p.o.), while it did not affect the blood pressure, respiratory rate and body temperature. Nicardipine at 30 mg/kg (p.o.) caused sustained hypotension and tachycardia. These results demonstrate the usefulness of the telemetry system using the common marmoset for evaluating the cardiovascular effects of drugs under physiological conditions.

Mentioned in this Paper

Callithrix jacchus jacchus
Cardiovascular System
Torsades De Pointes
Antihistamine [EPC]
Callithrix
Cardiovascular system DRUGS
Antihistamine brand of Diphenhydramine
Blood Pressure
Cebuella
Hypotension Adverse Event

About this Paper

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