Development of temporomandibular joint ankylosis in rats: a preliminary experimental study

International Journal of Oral and Maxillofacial Surgery
Gabriela Granja PortoV Silva

Abstract

The objective of this study was to evaluate a model for the development of temporomandibular joint ankylosis in rats using disc removal and articular damage. In 30 adult male Wistar rats, articular damage was induced and disc removal performed in the right joint to induce ankylosis. The rats were divided into groups according to the time of killing (7, 15, 30, 60 and 90 days). Maximal mouth opening, mandibular deviation, initial and final weights, and duration of surgery were recorded and evaluated. After death, the joints were submitted to histological study in order to score the ankylosis. The mean duration of surgery was 14.23 min. Mean difference between initial and final maximal mouth opening was 3.38 mm, being greatest at the 15-day evaluation and lowest at 90 days, and was statistically significant at 15 days (p=0.043), 30 days (p=0.027) and 60 days (p=0.027). No mandibular deviation was observed at any of the evaluation times. Histological scores increased with time of evaluation from 7 to 30 days, when they started to fall. This study model permitted the development of fibrous ankylosis in the majority of the animals, and no bony bridge was observed between the mandibular condyle and the temporal bone.

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Citations

Apr 18, 2012·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Ying-Bin YanE Xiao
May 28, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Ying-Bin YanYi Zhang
Feb 25, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Suzana Célia de Aguiar Soares CarneiroAuremir Rocha Melo
Sep 6, 2011·International Journal of Oral and Maxillofacial Surgery·G G PortoE S S Andrade
May 12, 2010·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Lucimar RodriguesJoão Gualberto C Luz
Feb 19, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Jian SunXuecai Yang
Feb 12, 2009·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Zhi LiZu-Bing Li
Nov 2, 2011·Acta Cirúrgica Brasileira·Reginaldo Inojosa Carneiro CampelloGabriela Granja Porto

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