Development of the amygdalohypothalamic projection in the mouse embryonic forebrain

Anatomy and Embryology
H AizawaS Yuasa

Abstract

The amygdalohypothalamic projection, a major component of the stria terminalis, is involved in the conduction of emotional and olfactory information integrated in the amygdala to the hypothalamus to elicit emotional reactions. Despite the extensive studies on functional aspects of the amygdaloid complex, developmental mechanisms of the amygdala and related structures are still poorly understood. To investigate the development of the amygdalohypothalamic projection in the mouse embryonic brain, carbocyanine dye was applied to the amygdala to label the growing axons anterogradely and to the hypothalamus to label the amygdaloid neurons retrogradely. The initial outgrowth of the stria terminalis was found to be as early as E11.5. The pathway crossed in a saddle over the internal capsule, another prominent connection in the developing forebrain of the mammalian embryo. Bipolar immature neurons were distributed along the stria terminalis at the telencephalo-diencephalic boundary, and the internal capsule was also surrounded by these cells. These cells expressed immunoreactivities to calretinin and the lot-1 antigen which has been shown to be involved in guidance of the developing lateral olfactory tract. Ultrastructural analysis reve...Continue Reading

Citations

Sep 4, 2007·Brain Research Reviews·Christie D FowlerZuoxin Wang
Feb 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Marion SotoC Ronald Kahn
Aug 3, 2021·Frontiers in Molecular Biosciences·Bruce R SoutheySandra L Rodriguez-Zas

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