Development of the cerebellum with particular reference to cellular differentiation in the external granular layer

Early Human Development
J E BellA Gordon

Abstract

Immunocytochemical evidence of differentiation in developing human cerebellum is presented in this study. Antibodies to neuron specific enolase, neurofilament protein, glial fibrillary acidic protein, vimentin, cytokeratin, epithelial membrane antigen and lymphoid markers, DLC and Leu 7 were used. The external granular layer showed positivity with neuronal markers between 27 weeks gestation and 4 months postnatal, but was negative for all other markers including glial fibrillary acidic protein. Characteristic staining reactions were noted in the other cerebellar layers. Monoclonal antibodies, UJ13A (pan-neuroectodermal marker) and G10 (localising microtubule-associated protein MAP1x) were also used in a limited number of cryostat sections and were positive and negative, respectively, in the external granular layer. The results of this study are discussed in relation to the theory that the external granular layer may be one source of medulloblastomas.

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Citations

Oct 18, 2013·Neuropathology and Applied Neurobiology·Simon M L PaineNeil J Sebire
Jan 30, 2015·Frontiers in Cellular Neuroscience·Hassan MarzbanMojgan Rastegar
May 22, 2020·International Journal of Legal Medicine·Jakob MatschkeMarkus Glatzel

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